5-Methylcytosine (5mC) is a methylated form of the DNA base cytosine (C) that regulates gene transcription and takes several other biological roles. [1] When cytosine is methylated, the DNA maintains the same sequence, but the expression of methylated genes can be altered (the study of this is part of the field of epigenetics ). 5 ...

2022年10月18日 · 5-methylcytosine (m 5 C) is one of the most prevalent modifications of RNA, playing important roles in RNA metabolism, nuclear export, and translation. However, the potential role of RNA m 5 C methylation in innate immunity remains elusive. Here, we show that depletion of NSUN2, an …

2017年4月18日 · 5-methylcytosine (m 5 C) is a post-transcriptional RNA modification identified in both stable and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in mRNA...

dna 脱甲基涉及被动和主动脱甲基的两个过程来实现： 5- 甲基胞嘧啶 (5mc) 作为 d na 修饰的主要形式。 结构上，甲基通过牢靠的碳-碳双键与胞嘧啶碱基的 5 位连接，为直接去除甲基加了一层保险。机制上，前文提到的 dnmt3 以及官能伙伴 uhrf1 一起协助维持这种状态。

2019年1月30日 · In eukaryotes, 5-methylcytosine in DNA (5mC) and its oxidized derivatives (5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC)) are the most prominent modifications and have been suggested to contribute to epigenetic gene regulation through a variety of different mechanisms (reviewed in [2]).

5-甲基胞嘧啶（5-methylcytosine）为胞嘧啶受到甲基化之后，附加一个甲基于5号碳上的的型态，结构改变，但与互补碱基的配对性质不变。 5-甲基胞嘧啶是一种 表观遗传修饰 ，参与的 酵素 称为 DNA 甲基转移酶 （DNA methyltransferase）。

The nucleobase modification 5-methylcytosine (m (5)C) is widespread both in DNA and different cellular RNAs. The functions and enzymatic mechanisms of DNA m (5)C-methylation were extensively studied during the last decades.

2022年4月1日 · As reversible epigenetic modifications, m 5 C modifications of RNA affect the fate of the modified RNA molecules and play important roles in various biological processes including RNA stability control, protein synthesis, and transcriptional regulation. Furthermore, accumulative evidence also implicates the role of RNA m 5 C in

5hmC是继5mC被称为“第5 个碱基”之后的“第6 个碱基”。 [1] 5-羟甲基胞嘧啶在哺乳动物的不同组织间存在差异性分布, 这种差异还会随着年龄、疾病等因素发生变化。 所有的哺乳动物基因组中都含有5-羟甲基胞嘧啶，但是其水平在不同类型细胞中相差很大，在 中枢神经系统 的神经细胞中含量最高。 5-羟甲基胞嘧啶具体的功能还不明确，但是被认为可以调控 基因表达 以及促进DNA去甲基化，这一假设是基于人工的包含5-羟甲基胞嘧啶的DNA一旦转入 哺乳动物细胞 中就会转化为未 …

In this review, we outline the current detection methods of m 5 C in RNA, explore their advantages and disadvantages, and review the m 5 C distribution pattern and advances in RNA m 5 C methyltransferases. Additionally, we evaluate the physiological roles and pathological implications related to m 5 C modification. 2.