MDA-5（Melanoma differentiation-associated gene 5）是天然免疫系统中的一种重要模式识别受体，能够特异性识别一些特定RNA病毒的RNA。 在黑色素瘤分化中，MDA-5的作用机制主要 …

MDA5 (melanoma differentiation-associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans. [5] MDA5 is part of the RIG-I-like …

Anti-Melanoma Differentiation-Associated gene 5 (MDA-5) Dermatomyositis (MDA5, DM) is a recently identified subtype of myositis characteristically associated with Rapidly Progressive …

2023年11月3日 · Anti-MDA5 (Melanoma differentiation-associated protein-5) positive dermatomyositis (MDA5 + -DM) is characterised by rapidly progressive interstitial lung disease …

INTRODUCTION: Anti-MDA5 (Melanoma differentiation-associated gene 5) dermatomyositis is a rare, systemic, autoimmune disease characterized by rapidly progressive interstitial lung …

2024年2月22日 · MDA5 是一个蛋白分子，即黑色素瘤分化相关基因5（MDA5）编码蛋白。 MDA5 是进入宿主的胞内病毒 RNA 的主要受体蛋白。 MDA-5 广泛表达大多数组织中，通常在静息 …

Melanoma differentiation-associated gene 5 (MDA5) is a recently described autoantigen target in a subset of patients with dermatomyositis. Anti-MDA5 dermatomyositis is characterized by a …

2023年12月6日 · Anti-melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (MDA5-DM) is a distinct subtype of dermatomyositis characterized by...

MDA5 is one such sensor of virus presence and is activated by RNA. MDA5 is required for immunity against several classes of viruses, including picornaviruses. Recent work showed …

Anti-melanoma differentiation–associated gene 5 (MDA5) dermatomyositis exhibits unique clinical features including mucocutaneous ulceration, palmar papules, nonscarring alopecia, …