Fluorodeoxyuridylate, [1] also known as FdUMP, 5-fluoro-2'-deoxyuridylate, and 5-fluoro-2'-deoxyuridine 5'-monophosphate, is a molecule formed in vivo from 5-fluorouracil and 5-fluorodeoxyuridine. FdUMP acts as a suicide inhibitor of thymidylate synthase (TS).

一次口服本品800mg，1~2小时后未转换体的血清中浓度达最高值约1Ug/ml，其后迅速下降；5-FU的浓度亦在1-2小时后达最高值。肿瘤组织中的5-FU浓度比周围正常组织及血液呈更高值。5’-DFUR经PYNPase分解成5-FU与5-脱氧核糖-1-磷酸，其代谢产物主要由尿中排泄。

5-fu本身并无生物学活性，必须在体内转变成一磷酸脱氧氟尿嘧啶核苷( fdump) 或三磷酸氟尿嘧啶核苷（futp），才能发挥抗癌作用。 FdUMP与dUMP的结构相似，是胸苷酸合酶的抑制剂，阻断dTMP的合成，见下图。

2024年9月19日 · 1.FdUMP： 有效抑制DNA合成的关键代谢物，通过与TS结合阻止胸苷酸生成。 2.FUTP： 掺入RNA中，干扰RNA的转录和翻译功能。 3.FdUTP： 插入到DNA链中，导致DNA链断裂，进一步阻碍肿瘤细胞的DNA修复。 5-Fluorouracil、其前药和其他典型药物在癌细胞中的代 …

2009年10月1日 · To specifically quantify several metabolites of 5-fluorouracil (5-FU) and two endogenous monophosphate nucleotides, we developed an original method based on a liquid chromatography–tandem mass spectrometry (LC-MS/MS).

2009年10月1日 · A LC-MS/MS methodology was developed for the quantitative determination of 5-FU, 5-FUrd, 5-FdUrd, 5-FdUMP, dUMP, TMP in cell culture systems. This method provides accuracy, specificity, sensitivity for the analytes studied, without the safety requirements associated with radioactive substance handling.

5-氟-2′-脱氧尿苷-5′-单磷酸盐（fdump）是一种 dna 合成抑制剂。 FdUMP 与 RNA 合成抑制剂 3′-C-ethinylcytidine 一起在纳摩尔浓度下诱导宫颈癌细胞死亡。 安全信息

5- 5-fluoro-2′-deoxyuridylate (FdUMP) is an intracellularly generated metabolite of 5-Fluorouracil (5-FU), a widely used reagent in molecular biology to study DNA synthesis and metabolism.

2009年10月1日 · To specifically quantify several metabolites of 5-fluorouracil (5-FU) and two endogenous monophosphate nucleotides, we developed an original method based on a liquid chromatography-tandem mass spectrometry (LC-MS/MS).

2022年2月9日 · The major metabolite of the anticancer agent 5-fluorouracil (5-FU) is 5-fluorodeoxyuridine monophosphate (FdUMP), which is a potent inhibitor of thymidylate synthase (TS). Recently, we hypothesized that 5-FU-resistant colorectal cancer (CRC) cells have increased levels of TS protein relative to 5-FU …