GW 590735 is a potent and selective PPARα agonist. GW 590735 shows EC50 =4 nM on PPARα and at least 500-fold selectivity versus PPARδ and PPARγ. GW 590735 can be used for the research of dyslipidemia [1].

GW 590735 sodium is a potent and selective PPARα agonist with activity in regulating lipid metabolism. GW 590735 significantly increased high-density lipoprotein (HDL) cholesterol, decreased low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) cholesterol, and significantly reduced

GW 590735 is a potent and selective agonist of PPARα with an EC 50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ. 1. WARNING This product is not for human or veterinary use.

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GW 590735 (0.5-5 mg/kg; orally twice a day for 5 days) is able to lower LDLc and triglycerides (TG) and increase HDL cholesterol in the Apo-A-I-transgenic mouse model (male C57BL/6 mice transgenic for human ApoA-I).

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GW 590735显著增加了高密度脂蛋白（HDL）胆固醇，减少了低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）胆固醇，并显著降低了甘油三酯。 GW 590735的HDL胆固醇最大增加值分别为37%、53%和84%，与苯扎贝特、托塞曲普比和GW 590735相比。 GW 590735 sodium is a potent and selective PPARα agonist with activity in regulating lipid metabolism.

gw 590735表现出相似的pparα激动剂效能，与鼠和人ppars相比的选择性。 gw 590735降低了低密度脂蛋白和vldl胆固醇，以及以剂量依赖性增加的高密度脂蛋白胆固醇方式，这表明在治疗高甘油三酯血症和血脂异常方面有显着的治疗益处.

艾美捷gw 590735 是一种有效且选择性的 pparα 激动剂，其表达 gal4 反应性报告基因的 ec 50值为 4 nm，比pparγ 和 pparδ 的选择性高至少 500倍。 艾美捷GW Cayman 590735储存注意事

gw 590735降低了 低密度脂蛋白和VLDL 胆固醇，以及以剂量依赖性增加的高密度脂蛋白胆固醇方式，这表明在治疗 高甘油三酯血症和血脂异常方面有显着的治疗益处.