5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine), also known as O-methylbufotenin or mebufotenin (INN Tooltip International Nonproprietary Name), is a naturally occurring psychedelic of the tryptamine family.

5-Methoxy-N,N-dimethyltryptamine (also known as 5-MeO-DMT) is a naturally-occurring psychedelic substance of the tryptamine class. It is structurally related to DMT and 5-HO-DMT ( bufotenin ) and is reputed to produce the most powerful and intense psychedelic states within the entire class. 5-MeO-DMT produces its effects by binding to serotonin ...

Potential Benefits: 5-MeO-DMT induces feelings of awe, visual and auditory hallucinations, and other sensations similar to other classic psychedelics. Potential Risks and Side Effects: 5-MeO-DMT is sometimes paired with MAOIs, a class of antidepressants, which can make the experience longer and more intense.

2022年12月5日 · 5-MeO-DMT is a research chemical psychedelic of the tryptamine class, four to six times more powerful than its better-known cousin, DMT (N,N-dimethyltryptamine).

2023年12月11日 · 5-MeO-DMT is a tryptamine being developed as a potential antidepressant that may display a distinct therapeutic mechanism due to its unique pharmacology and subjective effects compared to typical psychedelics. In this article, we parallel the relatively distinct phenomenology and behavioral effects …

Assessing 5-MeO-DMT's impact on anxiety, depression, and emotional well-being. Understanding its pharmacokinetics (absorption, distribution, metabolism, and excretion). Evaluating its safety profile and identifying potential side effects, both mild and severe.

2024年5月8日 · We show that a 5-HT 1A -selective 5-MeO-DMT analogue is devoid of hallucinogenic-like effects while retaining anxiolytic-like and antidepressant-like activity in socially defeated animals.

实验表明尽管致幻剂可以激动5-羟色胺（5-HT）1A/2A/2C受体等多种5-羟色胺受体，但其致幻作用主要与激动5-HT 2A 受体有关。 5-MeO-DMT与其它的致幻剂相类似，对多种5-羟色胺（5-HT）受体亚型具有激动作用，属于非选择性5-HT受体激动剂。 其与5-HT 2A 受体的亲合力远低于5-HT 1A 受体，但其活性代谢产物Bufotenine与5-HT 2A 受体的亲合力显著增强。 对致幻剂作用机制的研究也带动了探索致幻剂在精神疾病中的治疗意义，包括抑郁、焦虑等。 在抑郁方面的研究显示 …

2025年1月15日 · 5-MeO-DMT (N,N-Dimethyl-5-methoxytryptamine) is a psychedelic tryptamine, 4 – 6 times stronger than the better-known DMT (N,N-dimethyltryptamine).

2023年4月4日 · One short-acting psychedelic is 5-MeO-DMT, which has been associated with improvement in depression and anxiety symptoms in early phase clinical studies. However, relatively little is known about...