2017年2月15日 · Crystallography provides structural information crucial for fragment optimization, however several criteria must be met to screen directly on protein crystals as soakable, well-diffracting specimen must be available. We screened a 96-fragment library against the tRNA-modifying enzyme TGT using crystallography.

cl19224 (13-374): This is a family of queuine tRNA-ribosyltransferases EC:2.4.2.29, also known as tRNA-guanine transglycosylase and guanine insertion enzyme. Queuine t... * Click molecule labels to explore molecular sequence information. Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.

PDB entry 5utj View 5utj on RCSB PDB site Description: Crystal Structure of TGT in complex with 2,6-dioxy-8-azapurine, 2,6-dioxy-8-azapurine, 2,6-dioxy-8-azapurine Class: transferase Keywords: TGT, tRNA, guanine exchange enzyme, transglycosylase, fragments, transferase Deposited on 2017-02-15, released 2018-03-07

Fragments as Novel Starting Points for tRNA-Guanine Transglycosylase Inhibitors Found by Alternative Screening Strategies. Download full validation report.

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proteopedia link proteopedia link Crystal Structure of TGT in complex with 2,6-dioxy-8-azapurine, 2,6-dioxy-8-azapurine, 2,6-dioxy-8-azapurine

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Crystal Structure of TGT in complex with 2,6-dioxy-8-azapurine, 2,6-dioxy-8-azapurine, 2,6-dioxy-8-azapurine

2019年12月6日 · For the structure of TGT in complex with J79 (PDB: 5UTJ) the average B-factor of the ligand remains high despite refining occupancy to 100 %. Chemicalize 36 developed by ChemAxon 37 was used for name-to-structure generation and SMILES code notation.