Thioflavin-positive tau aggregates complicating quantification …
2021年1月15日 · We observed ThS-labeled insoluble protein aggregates that were not positive for anti-Aβ antibodies, 6E10 or 4G8, in the cortical and hippocampal regions of both male and …
Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific …
2012年3月16日 · Western analysis demonstrates that an APP C-terminal antibody (CTF1565), 22C11 and 6E10 detect a ~100 kDa band consistent with APP, while MOAB-2 does not …
Systematic phenotyping and characterization of the 5xFAD …
2021年10月15日 · Here we conducted a detailed phenotypic characterization of the 5xFAD model on a congenic C57BL/6 J strain background, across its lifespan – including a seldomly …
Rescue of Alzheimer’s disease phenotype in a mouse model by ...
2023年8月9日 · Our study showed that single systemic wild-type (WT) hematopoietic stem and progenitor cell (HSPC) transplantation rescued the AD phenotype in 5xFAD mice and that …
A proteomics analysis of 5xFAD mouse brain regions reveals the …
2023年7月20日 · We found a strong correlation between Arl8b- and 6E10-stained structures in hippocampal tissues of all three ages (Fig. 5 f), suggesting that the time-dependent formation …
The different number of plaques were detected in 6E10
Results The new mouse model, called 5xFAD TAU, shows accelerated cognitive impairment at 2 months of age, increased number of Aβ depositions at 4 months and neuritic plaques at 6 …
Axonal and myelinic pathology in 5xFAD Alzheimer’s mouse …
2017年11月27日 · Cervical (C7-C8), thoracic (T12) and lumbar (L4-5) spinal cross sections from 5xFAD and wild type mice at different ages (n = 3 for 11 week; n = 4 for 19 week; and n = 5 for …
Targeting soluble amyloid-beta oligomers with a novel nanobody
2024年7月12日 · In-vitro assays and in-vivo studies using 5XFAD mice indicate that the fluorescein (FAM)-labeled E3 nanobody recognizes both SAβOs and amyloid-β plaques. The …
(A) Immunostaining of Aβ peptide (anti-Aβ 6E10, red) and …
In 5xFAD mice, L5 neurons from the anterior frontal cortex and other cortical regions show earlier, more severe Aβ pathology than the hippocampus, as a result cortical LTP impairment is ...
Glial Gap Junction Pathology in the Spinal Cord of the 5xFAD …
2022年12月9日 · In the present study, we investigated for the first time the expression profiles of astroglial GJ proteins Cx43/Cx30 and oligodendroglial Cx47/Cx32 in relation to AD pathology …