Eukaryotic large ribosomal subunit (60S) - Wikipedia
The core of the 60S subunit is formed by the 28S ribosomal RNA (abbreviated 28S rRNA), which is homologous to the prokaryotic 23S rRNA, which also contributes the active site (peptidyl …
请教5.8s 16s 18s 26s 28s分别指什么？ - 微生物 - 小木虫 - 学术 科 …
真核生物80S核糖体中包含4种沉降系数不同的rRNA，其中，40S核糖体亚基（小亚基）中包含18S rRNA，而60S核糖体亚基（大亚基）中包含5S rRNA、5.8S rRNA和28S rRNA。 即真核细胞 …
Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes
2017年12月14日 · Using cryo-EM, we solved structures of early 60S biogenesis intermediates at 3.3 Å to 4.5 Å resolution, thereby providing insights into their sequential folding and assembly …
Principles of human pre-60 S biogenesis - Science | AAAS
Later nuclear pre-60 S states reveal how assembly factors interchange is used to drive irreversible fine tuning of functional centers. Additionally, by using engineered human rRNAs, …
Eukaryotic Ribosome Biogenesis: The 60S Subunit - PMC
Consecutive stages of large ribosomal subunit (60S) maturation are shown, starting with the earliest stages in the nucleolus, through stages in the nucleoplasm, and finally in the …
60S ribosome biogenesis requires rotation of the 5S ... - Nature
2014年3月24日 · Here, we present the first sub-nanometre cryo-EM structure of a eukaryotic 60S ribosomal subunit assembly intermediate, and position several biogenesis factors—Rlp7, …
Visualizing the nucleoplasmic maturation of human pre-60S …
2023年7月25日 · After early assembly events on nascent rRNA in the nucleolus, pre-60S particles undergo continuous maturation steps in the nucleoplasm, and prepare for nuclear export. …
The rDNA Loci—Intersections of Replication, Transcription, and …
Genes encoding 5S rRNA, which is a part of the large 60S ribosomal subunit, together with 25S and 5.8S rRNA, are localized either in clusters separated from those of 45S rDNA (S-type …
Principles of 60S ribosomal subunit assembly emerging from …
In the yeast Saccharomyces cerevisiae, the large 60S subunit that hosts the catalytic peptidyl transferase center (PTC) contains 25S rRNA (3396 nucleotides), 5.8S rRNA (158 nucleotides), …
EMBO Reports丨程净东课题组揭示60S核糖体组装的新机制
2023年5月4日 · 在以往研究的基础上，研究人员通过进一步的生化和冷冻电镜手段解析了9种不同的嗜热毛壳菌60S核糖体前体在核仁阶段的结构，分辨率达到了2.7 Å–3.6 Å，详细揭示了pre …