2018年8月7日 · In crystal structures the SAP domain engages the cleft between NBD subdomains Ia and IIa, stabilizing the ADP-bound conformation and clashing with the interdomain linker that occupies this site in ATP-bound BiP. MANF inhibits both ADP release from BiP and ATP binding to BiP, and thereby client release.

2019年2月1日 · Atomic coordinates of the X-ray structures were deposited in the Protein Data Bank (PDB) with accession codes 6H9U (BiP NBD in complex with MANF SAP), 6HA7 (BiP NBD in complex with MANF), and...

where 6HAB is the enthalpy of melting and dissociation of one mole of pure solid AnB, and HA*, HB* are the molar enthalpies of pure liquid A and B. The differential equation becomes

2019年2月6日 · 6hab: MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP.

3D Structure of chain 6HAB_A - CRYSTAL STRUCTURE OF BIP V461F (APO) - 6HAB | canSARS

Biological Unit for 6HAB: monomeric; determined by author and by software (PISA)

6hab is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. [ BIP_CRIGR] Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity).

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6HAB Crystal structure of BiP V461F (apo) Summary for 6HAB. Entry DOI: 10.2210/pdb6hab/pdb: Descriptor: Endoplasmic reticulum chaperone BiP, DI(HYDROXYETHYL)ETHER (3 entities in total) Functional Keywords: bip, grp78, hsp70, chaperone: Biological source: Cricetulus griseus (Chinese hamster) Total number of polymer chains: 1: