2016年2月15日 · Here we show that the 7SK small nuclear RNA (snRNA) inhibits enhancer transcription by modulating nucleosome position. 7SK occupies enhancers and super enhancers genome wide in mouse and human...

The 7SK small nuclear RNA is a multifunctional transcriptional regulatory RNA that controls the nuclear activity of the positive transcription elongation factor b (P-TEFb), specifically targets P-TEFb to the promoter regions of selected protein-coding genes and promotes transcription of RNA polymerase II-specific spliceosomal small nuclear RNA g...

2016年3月18日 · 7SK is a small nuclear RNA (snRNA) that, as part of a specific small nuclear ribonucleoprotein (snRNP) complex, regulates promoter-proximal pausing during transcription. Using a series of...

2019年5月15日 · NCBI's Gene Expression Omnibus (GEO) is a public archive and resource for gene expression data.

2021年1月7日 · Subsequent gain of neuronal identity requires upregulation of a small nuclear RNA, RN7SK, which induces accessibilities of chromatin regions and neuronal gene activation to push cells to a neuronal state. Our study defines deterministic components in the microRNA-mediated reprogramming cascade.

7SK-Baf Axis Controls Pervasive Transcription at Enhancers. Flynn RA, Do BT, Rubin AJ, Calo E, Lee B, Kuchelmeister H, Rale M, Chu C, Kool ET, Wysocka J, Khavari PA, Chang HY (2016) Nat Struct Mol Biol. 2016 Feb 15.

Here we show that the 7SK small nuclear RNA (snRNA) inhibits enhancer transcription by modulating nucleosome position. 7SK occupies enhancers and super enhancers genome-wide in mouse and human cells, and 7SK is required to limit eRNA initiation and synthesis in a manner distinct from promoter pausing.

Clustered elements at super enhancers uniquely require 7SK to prevent convergent transcription and DNA-damage signaling. 7SK physically interacts with the BAF chromatin-remodeling complex, recruits BAF to enhancers and inhibits enhancer …

2016年3月16日 · This 7SK-mediated BAF recruitment was shown to prevent extensive transcription at super-enhancers, which often leads to convergent mRNA synthesis (occurring simultaneously at both DNA strands)...

7SK-BAF axis controls pervasive transcription at enhancers. Nat Struct Mol Biol. 2016 Feb 15. doi: 10.1038/nsmb.3176.