Background and purpose: Lipoxin A4 (LXA4) has been reported to reduce inflammation in several neurological injury models. We studied the effects of LXA4 on neuroinflammation after subarachnoid hemorrhage (SAH) in a rat model. Methods: Two hundred and thirty-eight Sprague-Dawley male rats, weight 280-320 g, were used. Exogenous LXA4 (0.3 and 1.0 ...

The aim of this study was to investigate the protective effects and underlying anti-oxidative molecular mechanism of lipoxin A4 (LA4) in rats with ischemia/reperfusion (I/R)-injured skeletal muscle. A rat model of I/R-injured skeletal muscle was obtained by subjecting rats to a 3-h ligation of the right femoral artery followed by 3 h of ...

A rat model of monosodium iodoacetate (MIA)-induced KOA was constructed and intervened with moderate-intensity treadmill exercise and intraperitoneal injection of PHTPP to investigate the effects of the LXA 4 intracellular receptor ESR2 on exercise therapy.

This study aims to investigate the pre- and postconditioning effects of lipoxin A4 (LXA4) on myocardial damage caused by ischemia/reperfusion (I/R) injury. Seventy-two rats were divided into 6 groups: sham groups (C1 and C2), I/R groups (I/R1 and I/R2), and I/R plus LXA4 preconditioning and postcond …

2021年7月14日 · In this study, we found that lipoxin A4 significantly ameliorated the lung injury after lung transplantation in rats. Lipoxin A4 not only reduced the ischaemia reperfusion induced inflammation, oxidative stress response and apoptosis in transplanted lung tissues, but also improved the endothelial function in vitro.

2025年1月1日 · LXA4 decreased cerebral infarction and brain water content, improved neurological deficits, and reduced the release of NETs-associated indicators (MPO, NE) in MCAO rats. LXA4 reduced NETs formation, MPO and NE levels in vitro.

2025年2月15日 · Since this study represents the first attempt to evaluate the therapeutic potential of aspirin-triggered lipoxin A4 (ATL) and its combination with cannabinoid receptor agonists in eliciting behavioral responses associated with mechanical allodynia, we chose to use male rats to establish baseline data in a controlled setting.

Our results showed that LXA4 treatment significantly promotes skin flap survival and attenuates I/R injury by inhibiting oxidative stress, apoptosis, and inflammatory factor release, evidenced by the decreased expression of malondialdehyde (MDA), lactate dehydrogenase (LDH), NF-κBp65, tumor necrosis factor α (TNF-α), ET, active Caspase-3 and Bax...

2020年11月22日 · Lipoxin A4 is an endogenous anti-inflammatory and antioxidant mediator. The present study determined the effects of lipoxin A4 on VILI. Twenty-four rats were randomized to the sham, VILI, and lipoxin A4 (LX4) groups. The rats in the VILI and LX4 groups received large-volume MV for 4 hours to simulate VILI.

近日，来自中国医科大学附属盛京医院骨科的研究者们在Redox Biol杂志上发表了题为“Lipoxin A4 ameliorates knee osteoarthritis progression in rats by antagonizing ferroptosis through activation of the ESR2/LPAR3/Nrf2 axis in synovial fibroblast-like synoviocytes”的文章，该研究表明LXA4通过激活ESR2/LPAR3/Nrf2轴抑制FLSs铁死亡，从而减轻膝关节骨关节炎的疼痛和病理进展。