AAK1小分子抑制剂BMS-986176的发现 - 知乎 - 知乎专栏
AAK1靶点的成药性连接蛋白相关激酶1 (AAK1)是治疗神经性疼痛的可行靶点，这在小鼠敲除表型中首次得到证实。 AAK1为 丝氨酸 /苏氨酸激酶的Arkl/Prkl家族的成员，且已被鉴定为PC12细 …
AAK1 Gene - GeneCards | AAK1 Protein | AAK1 Antibody
2024年12月24日 · AAK1 (AP2 Associated Kinase 1) is a Protein Coding gene. Diseases associated with AAK1 include Rabies and Hepatitis C Virus. Among its related pathways are …
AAK1 - Wikipedia
Adaptor-associated protein kinase 1 also known as AP2-associated protein kinase 1 is an enzyme that in humans is encoded by the AAK1 gene [5] [6] [7] and is involved in clathrin mediated …
Development of a novel AAK1 inhibitor via Kinobeads-based …
2024年3月20日 · TIM-098a could inhibit AAK1 activity in transfected cultured cells (IC 50 = 0.87 µM), indicating cell-membrane permeability of the compound. Overexpression of AAK1 in …
衔接子相关蛋白激酶1 (AAK1) 抑制剂抗病毒研究进展
2022年7月7日 · AAK1是调控AP-2蛋白μ2亚基 (AP2M1) 第156位苏氨酸 (T156) 磷酸化的特异性关键激酶。AAK1介导的AP-2蛋白μ2亚基磷酸化能够确保AP-2蛋白对货物膜蛋白分选信号的高亲 …
Recent progress in discovery of novel AAK1 inhibitors: from pain ...
Adaptor associated kinase 1 (AAK1), a member of the Ark1/Prk1 family of Ser/Thr kinases, is a specific key kinase regulating Thr156 phosphorylation at the μ2 subunit of the adapter …
AAK1相互作用蛋白的筛选及其调控细胞内整体翻译水平的研究
随后，在细胞内过表达aak1，发现细胞内整体翻译水平上升（图4c），而干扰aak1后整体翻译水平下降（图4d），提示aak1可以正向调控细胞内整体翻译水平。
Identification of an adaptor-associated kinase, AAK1, as a …
Here we identify and characterize a novel member of the Prk/Ark family of serine/threonine kinases, adaptor-associated kinase (AAK)1. We find that AAK1 copurifies with adaptor protein …
Development and therapeutic potential of adaptor-associated
2023年2月15日 · Adaptor-Associated Kinase 1 (AAK1), a Ser/Thr protein kinase, responsible for regulating clathrin-mediated endocytosis, is ubiquitous in the central nervous system (CNS). …
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat ...
2016年7月16日 · Using a nonbrain-penetrant AAK1 inhibitor and local administration of an AAK1 inhibitor, the relevant pool of AAK1 for antineuropathic action was found to be in the spinal …