2024年12月24日 · Adeno-associated virus (AAV) has been reported to integrate in a site-specific manner into chromosome 19 (a site designated AAVS1), a phenomenon that could be …

2024年10月28日 · Gene provides a unified query environment for genes defined by sequence and/or in NCBI's Map Viewer.

2020年12月8日 · Here, we propose a new method, using only viral vectors, to efficiently integrate Cas9 into the AAVS1 locus by exploiting the advantages of lentiviral and AAV vectors for …

2017年4月25日 · Adeno-associated virus integration site 1 (AAVS1) in the human genome is a safe harbor for transgene integration via the CRISPR technology. It is transcriptionally active …

2024年10月28日 · Characterization of a preferred site on human chromosome 19q for integration of adeno-associated virus DNA by non-homologous recombination. Kotin RM, et al. EMBO J, …

2011年12月1日 · The AAVS1 site in chromosome 19 (position 19q13.42) was identified as a repeatedly recovered site of integration of wild-type AAV in the genome of cultured human cell …

In the latent state, AAV is found integrated site specifically into the host genome at chromosome 19q13.4 qtr (AAVS1), the only animal virus known to integrate in a defined location.

Here, we describe the strategy for targeting the AAVS1 site with an inducible Neurogenin-2 (Ngn2) donor template by CRISPR/Cas9 in hiPSCs, which facilitates generation of an …

As part of its lysogenic cycle, wild-type AAV integrates into the host genome at a specific site, AAVS1 on human chromosome 19. This site is favored due to the presence of a Rep binding …

2024年10月28日 · Clinical resource with information about AAVS1, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, …