ABCA7 could impact AD pathogenesis through a variety of mechanisms, including regulation of APP processing and clearance of Aβ through phagocytosis. Overall, the identification of …

2018年11月30日 · The p.A1527G allele of Abca7 is a common variant (minor allele frequency 0.16 in ExAc and HEX), which imparts a slightly increased risk for AD (odds ratio …

CRISPR/cas9 was used to generate a knock-out mutation of the Abca7 gene of double mutant mice with a humanized APOE4 gene and the p.R47H point mutation knocked into the mouse …

2024年9月19日 · They found, for example, that the A1527G variant in ABCA7 provoked expression changes in groups of genes involved in immune responses, cell cycle, myelination, …

2022年11月23日 · From this “mega-sample” of exomes, co-first authors Holstege, Marc Hulsman of Amsterdam University Medical Center, and Camille Charbonnier in Normandie found that in …

2020年10月22日 · It pinned ApoE4 and ABCA7 as risk genes, and pulled out a novel variant in the intergenic region 5q35. A subsequent ADGC study reported that, among black Americans, …

2015年3月26日 · Although ABCA7 is a member of the “A” subfamily of ATP-binding cassette transporters that were initially characterized by their capacity to transport lipids across …

2019年5月30日 · Contribution to Alzheimer's disease risk of rare variants in TREM2, SORL1, and ABCA7 in 1779 cases and 1273 controls. Neurobiol Aging. 2017 Nov;59:220.e1-220.e9. Epub …

2011年4月5日 · Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet. 2011 May;43(5):429-35. PubMed. …

2011年9月19日 · ABCA7 came up as a hit in a recent AD genomewide association study (ARF related news story on Hollingworth et al., 2011), and currently sits in the fourth position in the …