ABCE1 is an essential and highly conserved protein that is required for both eukaryotic translation initiation as well as ribosome biogenesis. The most studied homologues are Rli1p in yeast and Pixie in Drosophila .

2024年12月24日 · ABCE1 (ATP Binding Cassette Subfamily E Member 1) is a Protein Coding gene. Diseases associated with ABCE1 include Prostate Cancer and Congenital Myopathy 22B. Among its related pathways are Antiviral mechanism by IFN-stimulated genes and Cytokine Signaling in Immune system.

ABCE1 protein regulates a broad range of biological functions including viral infection, tumor cell proliferation, and antiapoptosis. (Review) For binding of WT HIV-1 Gag to the cellular ATPase ABCE1, which facilitates HIV-1 capsid assembly, the basic residues in the nucleocapsid domain of Gag are required but the cysteine and histidine ...

2020年2月4日 · Here, we newly identified that ATP-binding cassette sub-family E member 1 (ABCE1), which is also known as RNase L inhibitor (RLI), is involved in the regulation of exogenous RNA decay. ABCE1 directly binds to form a complex with RNase L and accelerates RNase L dimer formation in the absence of 2'-5' oligoadenylates (2-5A).

ABC 基因分为七个不同的亚家族 (ABC1、MDR/TAP、MRP、ALD、OABP、GCN20、White) 。 这种蛋白质是 OABP 亚家族的成员。 这种蛋白质也称为 RNase L 抑制剂，其功能是阻断核糖 …

ABCE1 基因全称为ATP结合盒E1 (ATP-binding cassette E1)，又称为RNase L抑制因子 [1 - 2]。 近年来报导ABCE1主要参与真核生物蛋白翻译和核糖体回收，HIV-1病毒壳组装 [3 - 6]。 ABCE1 还与肺癌密切相关，即 ABCE1 基因是一个参与肺癌转移的相关基因 [7 - 12]。 在前期工作中应用GST pulldown方法筛选出ABCE1蛋白的相互作用蛋白β-肌动蛋白，并且应用免疫共沉淀和免疫荧光染色初步证实了ABCE1和β-肌动蛋白的相互作用。 ABCE1 基因的编码蛋白能够通过与细胞骨 …

2010年1月29日 · Here, we report that ABCE1, a conserved and essential member of the ATP-binding cassette (ABC) family of proteins, promotes eukaryotic ribosomal recycling over a wide range of Mg 2+ concentrations. ABCE1 dissociates post-TCs into free 60S subunits and mRNA- and tRNA-bound 40S subunits. It can hydrolyze ATP, GTP, UTP, and CTP.

2023年12月1日 · ABCE1 silencing suppressed the expression of Cu-dependent HIF-1 target gene BNIP3, not that of Cu-independent IGF-2. The results demonstrate that ABCE1, as a Cu-binding protein, enters the nucleus under hypoxic conditions and inhibits FIH-1degradation of HIF-1α, thus promoting HIF-1 transactivation of angiogenic gene expression. 1. Introduction.

ATP binding cassette E1 (ABCE1) protein, also named RLI or HP68, is one member of ATP binding cassette superfamily. By forming a heterodimer with RNase L, ABCE1 protein inhibits the IFN-depended 2-5A/RNase L system and regulates a broad range of biological functions including viral infection, tumor …

Transmission and de novo association (TADA) analysis of whole-exome and whole-genome sequencing data from the Autism Sequencing Consortium, the Simons Simplex Collection, the MSSNG cohort, and the SPARK cohort in Trost et al., 2022 identified ABCE1 as an ASD-associated gene with a false discovery rate (FDR) < 0.1.