ABL (gene) - Wikipedia
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress …
ABL1 Gene - GeneCards | ABL1 Protein | ABL1 Antibody
2024年12月24日 · ABL1 (ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ABL1 include Congenital Heart Defects And Skeletal …
浅谈白血病常见致病基因BCR、ABL1、BCR-ABL1、JAK2的意义
二、 abl1基因. 原癌基因，abl1蛋白的sh3结构域缺失会使abl1成为原癌基因，这种基因会常常和其他多种基因发生“不正当关系”，常见的就是与bcr基因融合成bcr-abl1，变异后的。 三、 bcr …
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
Gene ID: 25, updated on 20-Feb-2025. This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, …
ABL1 gene - MedlinePlus
The ABL1 gene provides instructions for making a protein involved in many processes in cells throughout the body. The ABL1 protein functions as a kinase, which is an enzyme that …
Structure, Regulation, Signaling, and Targeting of Abl Kinases in ...
The Abl family of cytoplasmic tyrosine kinases consists of 2 members, Abl and Arg (Abl-related gene), encoded by the ABL1 and ABL2 genes in humans, and has important roles in various …
【AmBeed简析】解读BCR-ABL1：从作用机制到抑制剂应用的探索
2024年6月4日 · Imatinib是一种TKI（酪氨酸激酶抑制剂），专门针对BCR-ABL1融合蛋白活性，显著改善了大多数CML患者的生存期和预后，目前这种药物被认为是标准疗法。 Imatinib 与ATP …
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase [Homo sapiens ...
2025年2月9日 · Title: Human ABL1 deficiency syndrome (HADS) is a recognizable syndrome distinct from ABL1-related congenital heart defects and skeletal malformations syndrome. …
ABL 原癌基因 1，非受体酪氨酸激酶（ABL1）基因 | MCE
该基因是一种原癌基因，编码参与多种细胞过程的蛋白酪氨酸激酶，包括细胞分裂、粘附、分化和应激反应。 该蛋白的活性受其 SH3 结构域的负调控，因此删除编码该结构域的区域会导致致 …
Pathogenic variants causing ABL1 malformation syndrome cluster …
2020年11月22日 · ABL1 is a proto-oncogene encoding a nonreceptor tyrosine kinase, best known in the somatic BCR-ABL fusion gene associated with chronic myeloid leukaemia. Recently, …