2024年3月18日 · This study aims to identify the effect of Abx pretreatment from dextran sulfate sodium (DSS)-induced colitis and to evaluate whether Abx pretreatment has an enhanced effect on the protection of Clostridium butyricum Miyairi588 (CBM) from colitis.

2023年9月4日 · dss诱导的结肠炎小鼠表现出与uc患者相似的症状，其特征是体重减轻、腹泻、结肠缩短、炎症反应、肠道损伤和肠道生态失调。因此，dss已被广泛用于建立小鼠结肠炎模型。肠上皮细胞的上部有粘液，它可以阻止病原体、饮食抗原和毒素进入肠上皮。

ABX treatment completely protected the mice from colitis and abrogated the impact of fungi on colitis. Only untreated mice exhibited a strong colitis phenotype with significant weight loss (Fig....

2024年7月5日 · Our results showed that BZA significantly reduced DSS-induced colitis symptoms in mice, evidenced by decreased colon length shortening, lower histological scores, and increased expression of intestinal mucosal barrier-associated proteins, such as Claudin 1, Occludin, Zo-1, Mucin 2 (Muc2), and E-cadherin.

2022年11月10日 · 为了探索胃肠道真菌微生物群的生物地理分布特征，我们从C57BL/6小鼠的胃、空肠、回肠、盲肠和结肠等多个GI区域收集LUM和黏膜样本，并进行真菌核糖体DNA (rDNA)ITS测序 (图1A)。 真菌群落的非度量多维尺度分析显示，基于LUM与粘膜取样部位的聚集性较强，而非纵向位置 (图1B)。 进一步分析显示，无论纵向采样位置如何，LUM真菌菌群的多样性都很高，而粘膜相关真菌群落的多样性明显较低 (图1C)。 由于大肠承载着最高的真菌负荷，我们将进一 …

Oral BDX-01 administration significantly ameliorated the symptoms and pathological damage of DSS-induced acute colitis. Moreoever, 16S rRNA sequencing and enzyme activity analysis showed that BDX-01 treatment increased intestinal BSH activity and the abundance of bacteria harboring this enzyme.

2023年3月1日 · In this study, the intervention effect of Dendrobium fimbriatum Hook polysaccharide (cDFPW1) on UC was verified by constructing a dextran sulfate sodium (DSS)-induced colitis mouse model, and the protective effect of cDFPW1 on intestinal mucosal integrity in UC was explored by the co-culture system consisting of intestinal organoids and lamina p...

2020年1月1日 · Microbial disruption with Abx during colitis recovery induced visceral allodynia and hyperalgesia in Abx-treated mice (visceromotor response at 30 mm Hg: control, 0.01 ± 0.03 vs control + Abx, 0.05 ± 0.0; P < .05; area under the curve for colorectal distention: control, 0.1 ± 0.01 vs DSS + Abx, 0.22 ± 0.04; P < .01; Figure 2 A), independent ...

摘要：目的：采用不同抗生素组合（Antibioticcocktail，ABx）预处理的方法构造伪无菌小鼠模型，观察不同抗生素组合对小鼠生理功能、肠道炎症及肠道菌群的影响。 继而从肠屏障和免疫方面，观察丁酸梭菌MIYAIRI588对抗生素预处理后DSS肠炎小鼠的作用，并探索其对小鼠肠屏障、炎症细胞因子、免疫细胞、肠道菌群结构和短链脂肪酸代谢物的影响。 最后，探究丁酸梭菌MIYAIRI588菌体和上清液调节肠炎小鼠炎症稳态的机制。

目的：采用不同抗生素组合（Antibioticcocktail，ABx）预处理的方法构造伪无菌小鼠模型，观察不同抗生素组合对小鼠生理功能、肠道炎症及肠道菌群的影响。