ADAMTS (short for a disintegrin and metalloproteinase with thrombospondin motifs) is a family of multidomain extracellular protease enzymes. [1] 19 members of this family have been identified in humans, the first of which, ADAMTS1, was described in 1997. [2]

ADAM(A Disintegrin and Metallo-proteinases)和ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) 是基质锌依赖的金属蛋白酶，它们一起被称为 adamalysins。 ADAM 金属蛋白酶是跨膜和分泌蛋白，而 ADAMTS 是分泌形式。

2015年5月30日 · The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling, in inflammation and in vascular biology.

ADAMTS13 （a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13），又称 温韦伯氏因子裂解酶 （von Willebrand factor-cleaving protease，VWFCP）是一种含 锌 的 金属蛋白酶。 ADAMTS13可以裂解一种称为 温韦伯氏因子 （英语：von Willebrand factor） （vWf）的大型 凝血因子。

含Ⅰ型血小板结合蛋白基序的解聚蛋白样金属蛋白酶ADAMTSs (a disintegrin and metallo-proteinase with thrombospondin...

The ADAMTSs (a disintegrin and metalloproteinase with thrombospondin motifs) are a group of proteases that are found both in mammals and invertebrates. Since the prototype ADAMTS-1 was first described in 1997, there has been a rapidly expanding body ...

2023年12月9日 · ADAM and ADAMTS proteases have contributed to the development of pathological tissue remodeling in many diseases, mainly through the regulation of cell proliferation, apoptosis, migration and...

ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) is a novel family of extracellular proteases found in both mammals and invertebrates. Members of the family may be distinguished from the ADAM (a disintegrin and metalloprotease) family members based on the multiple copies of thro …

含Ⅰ型血小板结合蛋白基序的解聚蛋白样金属蛋白酶ADAMTSs (a disintegrin and metallo-proteinase with thrombospondin motifs)是一类新的Zn2+依赖的金属蛋白酶家族,广泛存在于哺乳动物和无脊椎动物体内.从1997年发现第一个ADAMTSs家族成员以来,迄今共有19个成员被发现,在保持凝血系统的稳态,器官生成,炎症,生育等方面有重要作用.尽管其中大部分酶的功能尚不清楚,但已有研究显示该家族成员与多种疾病密切相关.ADAMTSs与基质金属蛋白酶MMPs,解聚蛋白样金属 …

ADAMTS-1通过C -末端结合到血管内皮生长因子VEGF165的肝素结合区,从而阻断了VEGF受体VEGFR2的磷酸化,进而抑制内皮增殖和血管生成。 最近的研究表明, ADAMTS-1还可以通过活化有抗血管再生作用的基质糖蛋白Thrombospondin ( TSP )TSP 1和TSP 2,达到抗血管再生的作用。血管新生在肿瘤转移中起着关键作用。ADAMTS-1通过抑制血管的生成,可能参与了抑制肿瘤的发生发展。在非小细胞肺癌中, ADAMTS-1无论在mRNA水平还是蛋白水平,表达均显著下降,从而失去 …