2024年12月24日 · ADH5 (Alcohol Dehydrogenase 5 (Class III), Chi Polypeptide) is a Protein Coding gene. Diseases associated with ADH5 include Amed Syndrome, Digenic and Deficiency Anemia. Among its related pathways are formaldehyde oxidation II (glutathione-dependent) and Oxidation by cytochrome P450.

Alcohol dehydrogenase class-3 is an enzyme that in humans is encoded by the ADH5 gene. [5][6][7] This gene encodes glutathione -dependent formaldehyde dehydrogenase or the class III alcohol dehydrogenase chi subunit, which is a member of the alcohol dehydrogenase family.

2024年12月10日 · Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells. Bae S, et al. J Nutr, 2017 Apr. PMID 28228507, Free PMC Article; See all (99) citations in PubMed

乙醇脱氢酶 5 (III 类),chi 多肽： 该基因编码醇脱氢酶家族的一个成员。 该家族的成员代谢多种底物，包括乙醇、视黄醇、其他脂肪醇、羟基类固醇和脂质过氧化产物。

2013年2月25日 · Alcohol dehydrogenase 5 (ADH5) is a member of the mammalian alcohol dehydrogenase family of yet undefined functions. ADH5 was first identified at the DNA level in human and deer mouse.

2025年1月28日 · Enables S- (hydroxymethyl)glutathione dehydrogenase [NAD (P)+] activity; alcohol dehydrogenase (NAD+) activity; and identical protein binding activity. Acts upstream of or within several processes, including formaldehyde catabolic process; peptidyl-cysteine S-nitrosylation; and response to lipopolysaccharide. Located in mitochondrion.

4-step rapid multiplex IHC technique has been developed to characterize a spectrum of intraductal epithelial proliferations, including ductal hyperplasia of usual type, atypical intraductal hyperplasia, ductal carcinoma in situ and micro-invasive carcinoma.

该基因编码的蛋白可启动 S- (羟甲基) 谷胱甘肽脱氢酶活性；乙醇脱氢酶 (NAD+) 活性；和相同的蛋白质结合活性。 作用于多个过程的上游或内部，包括甲醛分解代谢过程；肽基-半胱氨酸 S-亚硝基化；和对脂多糖的反应。 位于线粒体中。 以多种结构表达，包括消化系统；中枢神经系统;泌尿生殖系统；外皮系统；和呼吸系统。 该基因的人类直系同源物与 AMED 综合征和哮喘有关。 与人 ADH5（酒精脱氢酶 5（III 类），chi 多肽）同源。 [由基因组资源联盟提供，2022 年 4 月]

在几个结构中表达，包括消化系统; 中枢神经系统; 生殖泌尿系统; 皮肤和附属结构; 和呼吸系统。这个基因的人类同源物涉及AMED综合征和哮喘。与人类ADH5(乙醇脱氢酶5(III类), chi多肽)正交。

2025年2月8日 · Results show that ADH5 removes endogenous formaldehyde to prevent DNA adducts, and protects with FANCD2, hematopoietic stem cells, hepatocytes, and nephrons from endogenous DNA damage.