2024年12月24日 · ADRB3 (Adrenoceptor Beta 3) is a Protein Coding gene. Diseases associated with ADRB3 include Body Mass Index Quantitative Trait Locus 11 and Overactive Bladder Syndrome. Among its related pathways are Activation of cAMP-Dependent PKA and Class A/1 (Rhodopsin-like receptors).

The beta-3 adrenergic receptor (β 3-adrenoceptor), also known as ADRB3, is a beta-adrenergic receptor, and also denotes the human gene encoding it. [5]

2025年2月8日 · ADRB3 adrenergic receptor is a key regulator of human myometrial apoptosis and inflammation during chorioamnionitis. Trp64Arg polymorphism of the beta-3 adrenergic receptor may be independently associated with hyperuricemia in males.

Silencing ADRB3 in human beige/brown adipocytes significantly reduced Fsk-induced leak respiration, maximal respiration, and spare respiratory capacity, which confirms that functional ADRB3 is required to fully increase uncoupled respiration.

The ADRB3 gene product (the β 3-adrenoceptor) belongs to a family of β-adrenergic receptors that mediate catecholamine-induced signaling. The receptor is mainly located in the adipose tissue where it is involved in the regulation of lipolysis and thermogenesis.

2022年2月10日 · Here, we show that ADRB3 is crucial in cell mobilization and differentiation. Immunohistochemistry revealed ADRB3 expression is significantly more frequent in breast cancer tissues than in...

2025年2月8日 · Title: ADRB3 induces mobilization and inhibits differentiation of both breast cancer cells and myeloid-derived suppressor cells.

2022年1月18日 · While resistant to classical desensitization pathways, its mRNA (Adrb3) and protein expression are dramatically downregulated after ligand exposure (homologous desensitization). β3-Adrenergic receptor downregulation also occurs after high-fat diet feeding, concurrent with catecholamine resistance and elevated inflammation.

2022年6月2日 · Background: The ADRB3 (β3-adrenergic receptors), which is predominantly expressed in brown adipose tissue (BAT), can activate BAT and improve metabolic health. Previous studies indicate that the endocrine function of BAT is associated with cardiac homeostasis and diseases.

该基因编码的蛋白质属于 β 肾上腺素能受体家族，它通过 g 蛋白的作用介导儿茶酚胺诱导的腺苷酸环化酶激活。该受体主要位于脂肪组织中，参与脂肪分解和产热的调节。肥胖和体重相关疾病与 β-肾上腺素能受体三种亚型的某些多态性相关，其中包括 adrb3 基因。