Oestrogen receptor α AF-1 and AF-2 domains have cell ... - Nature
2018年11月9日 · Here we show that deletion of AF-1 or AF-2 blocks pubertal ductal growth and subsequent development because both are required for expression of essential paracrine …
The AF1 and AF2 Domains of the Androgen Receptor Interact …
Our data supports this suggestion, with SRC1 bridging AF1 and AF2 by means of interactions between the glutamine-rich region and TAU5 and between the LXXLL motifs and AF2. Clearly, …
乳腺癌内分泌治疗常用药物一（选择性雌激素受体调节剂）
2023年7月24日 · 生理情况下，雌激素与er结合后，激活er上的转录活性区域af1和af2，促进靶基因转录并最终促进细胞增殖。 ER拮抗药TAM与E2竞争性结合ER，但仅使AF2失活，而AF1活性 …
A new compound targets the AF-1 of androgen receptor and …
EIQPN interacted with the AR-activation fragment-1 (AF-1) domain and blocked its androgen-independent activity, robustly decreased the protein levels of AR and variants in prostate …
Activation Functions 1 and 2 of Nuclear Receptors: Molecular …
2003年10月1日 · Structural Changes in AF-1 by Means Other than Coregulator Binding. Posttranscriptional events such as phosphorylation have been shown to affect the …
Synergy between estrogen receptor α activation functions AF1 and AF2 …
2000年8月8日 · We demonstrate here that TIF2 is able to bind to the isolated AF1 and AF2 simultaneously using distinct interfaces and that this simultaneous interaction can lead to …
The AF1 and AF2 domains of the androgen receptor interact with distinct ...
Here we demonstrate that p160 coactivators such as SRC1 (steroid receptor coactivator 1) interact directly with the N terminus in a ligand-independent manner via a conserved glutamine …
Transactivating function (AF) 2–mediated AF-1 activity of ... - PNAS
2012年12月4日 · We recently showed that two point mutations converting leucines 543 and 544 to alanines in helix 12 (AF2ER) minimized estrogen-dependent AF-2 transcriptional activation. A …
Structure and function of steroid receptor AF1 transactivation …
The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid …
An injury-induced mesenchymal-epithelial cell niche ... - Science
We observed AF1-derived AF2 cells, identified by coexpression of Notch3-ICD and Pdgfra-lineage reporter (tdTomato), spatially enriched within the severely damaged regions of the lung that …