Tracing the first hematopoietic stem cell generation in human …
2019年9月9日 · Long-term multi-lineage repopulating HSCs are detected firstly in the aorta–gonad–mesonephros (AGM) region at Carnegie stage (CS) 14 (32 days post coitus, …
Hematopoietic Stem Cell Development Is Dependent on Blood Flow - Cell …
During vertebrate embryogenesis, hematopoietic stem cells (HSCs) arise in the aorta-gonads-mesonephros (AGM) region. We report here that blood flow is a conserved regulator of HSC …
BMP and Hedgehog Regulate Distinct AGM Hematopoietic
2016年3月8日 · Hematopoietic stem cells (HSC), the self-renewing cells of the adult blood differentiation hierarchy, are generated during embryonic stages. The first HSCs are produced …
Engineering a niche supporting hematopoietic stem cell ... - Nature
2022年3月24日 · To identify the signals responsible for HSC formation, here we use single cell RNA-sequencing to simultaneously analyze the transcriptional profiles of AGM-derived cells …
Autophagy regulates the maturation of hematopoietic precursors …
2024年3月15日 · Hematopoietic stem cells (HSC) are at the apex of the adult hematopoietic hierarchy, providing all mature hematopoietic cells and multipotent progenitor cells. In the...
The hematopoietic stem cell niche: from embryo to adult - PMC
Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and finally …
专家点评Cell Res | 刘兵/兰雨团队解密人类造血干细胞起源 - 知乎
研究人员通过异种移植的功能分析，确认了人类的HSC于胚胎卡内基阶段（Carnegie stage，CS）14（妊娠后32天）最早出现在主动脉-性腺-中 …
Extensive Hematopoietic Stem Cell Generation in the AGM Region …
2008年7月3日 · We demonstrate that extensive generation of definitive HSCs in the AGM occurs predominantly through the acquisition of stem characteristics by the VE-cadherin + CD45 + …
Murine AGM single-cell profiling identifies a continuum of …
2022年1月20日 · HSCs first emerge in the aorta-gonad-mesonephros (AGM) region, where a rare subset of endothelial cells, hemogenic endothelium (HE), undergoes an endothelial-to …
Mapping human haematopoietic stem cells from haemogenic
2022年4月13日 · Human HSCs emerge in the aorta–gonad–mesonephros (AGM) region between Carnegie stages 13 and 17 (CS13–17; 4–6 weeks) through intra-aortic haematopoietic …
The hematopoietic stem cell niche: from embryo to adult
2018年1月22日 · Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal …
小鼠及人胚胎AGM区造血细胞与间充质干细胞的发育_百度百科
AGM（dorsal aorta-gonad-mesonephros, AGM）区是胚胎最早原位自发产生永久（definitive）造血干细胞（hematopietic stem cells, HSCs）的位点，组成AGM区的间质细胞则为永久造血提 …
Cell Res：解密人类造血干细胞起源_美必思医学编译 - Mebis
研究人员通过异种移植的功能分析，确认了人类的HSC于胚胎卡内基阶段（Carnegie stage，CS）14 （妊娠后32天）最早出现在主动脉-性腺-中 …
Definitive hematopoietic stem cells first develop within the major ...
The aorta–gonad–mesonephros (AGM) region is a potent hematopoietic site within the mammalian embryo body, and the first place from which hematopoietic stem cells (HSCs) …
Cell Research：精准解析造血干细胞的内皮起源及特化路径
2020年3月22日 · 造血干细胞（Hematopoietic stem cell, HSC）位于成体造血系统的最上游，具有自我更新能力并可产生所有类型的血液细胞。目前研究认为，HSC起源于胚胎发育中期的生血 …
IκBα controls dormancy in hematopoietic stem cells via retinoic …
2024年6月1日 · Overall, we identify a nuclear IκBα-PRC2 interactions as a regulatory axis controlling the balance between HSC proliferation and dormancy, starting from the AGM stage …
Cell子刊：程涛/程辉/周波/刘兵团队揭示人造血干细胞最早定植骨 …
2022年11月4日 · 有研究通过异种移植实验表明，HSC最早出现在胚胎卡内基阶段（Carnegie Stage，CS）14（妊娠后32天）的主动脉-性腺-中肾（AGM）区域。 随后HSC被释放到循环 …
Long-term engrafting multilineage hematopoietic cells ... - Nature
2024年9月2日 · Intraembryonic hematopoietic cells, whose descendants form the adult blood system, develop separately in the aorta–gonad–mesonephros (AGM) region, where they...
李专团队揭示细胞自噬调控造血干细胞前体细胞成熟的分子机制
2024年3月16日 · 研究团队利用自噬报告小鼠模型和条件基因敲除小鼠模型，结合单细胞转录组测序分析和体内外功能实验，揭示EHT过程中不同阶段细胞自噬状态的异质性且自噬状态与造血 …