Comparative analysis of the AIB1 interactome in breast cancer …
2021年1月8日 · In primary breast cancer, the coactivator AIB1 promotes estrogen receptor (ER) transcriptional activity to enhance cell proliferation. The function of the coactivator in ER + …
AIB1, a Steroid Receptor Coactivator Amplified in Breast and ... - Science
1997年8月15日 · We now report that AIB1 is a member of the SRC-1 family of nuclear receptor (NR) coactivators, that it is amplified and overexpressed in breast and ovarian cancer cell lines …
AIB1: A Transcriptional Coactivator Which Integrates Signaling …
2011年1月1日 · AIB1 is a relatively new oncogene initially described in 1997 as a steroid receptor coactivator, hence linking its function to hormonal response. However, new insights in AIB1 …
核激素受体转录共激活因子AIB1的研究进展
AIB1(amplified in breast cancer 1)是核激素受体转录共激活因子家族中的一员，又称作SRC-3、ACTR、TRAM-1、RAC3、NCOA3、P／CIP等。 作为新定义的一个原癌基因，它是由anzick …
Transcriptional Repression of AIB1 by FoxG1 Leads to Apoptosis in ...
In this study, we identified a novel interacting protein of AIB1, forkhead-box protein G1 (FoxG1), which is an evolutionarily conserved forkhead-box transcriptional corepressor. We show that …
癌基因AIB1促进肺腺癌转移的作用和分子机制 - 百度百科
《癌基因AIB1促进肺腺癌转移的作用和分子机制》是依托中山大学，由何立儒担任项目负责人的青年科学基金项目。 肺腺癌具有易转移预后差的特点。 AIB1是与多种肿瘤发生发展密切相关的 …
Overexpression of transcriptional coactivator AIB1 promotes ...
2010年3月22日 · Amplified in breast cancer 1 (AIB1) is a transcriptional coactivator for nuclear receptors and other transcription factors. AIB1 has an important role in malignancy of several...
AIB1 is a predictive factor for tamoxifen response in …
Clinical trials implicate the estrogen receptor (ER) coactivator amplified in breast cancer 1 (AIB1) to be a prognostic and a treatment-predictive factor, although results are not unanimous. We …
Cancer Res：肿瘤中的少量细胞或能作为促进癌症转移的关键“推 …
2021年6月21日 · 近日，一篇发表在国际杂志Cancer Research上题为“An AIB1 isoform alters enhancer access and enables progression of early stage triple-negative breast cancer”的研究 …
AIB1 Is a Conduit for Kinase-Mediated Growth Factor Signaling to …
We found that the transcriptional activity of AIB1, a ligand-dependent ER coactivator and a gene amplified preferentially in ER-positive breast cancers, is enhanced by MAPK phosphorylation. …