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2012年6月22日 · Avian influenza virus (AIV) outbreaks are worldwide threats to both poultry and humans. Our previous study suggested microRNAs (miRNAs) play significant roles in the regulation of host response to AIV infection in layer chickens.

2009年11月5日 · We hypothesize that miR-34b, miR-34c, miR-206, miR-1458 and miR-1612 might be some of the most important miRNAs associated with AIV infection. Significantly different miRNA expression pattern between lung and trachea suggests the regulatory mechanism of miRNAs on host response to the AIV infection between lung and trachea is distinct.

2020年11月9日 · Importantly, we found that ssc-miR-221-3p and ssc-miR-222 could also be specifically upregulated upon AIV infection in newborn pig tracheal epithelial (NPTr) cells and also exerted anti-AIV function. In summary, our study indicated that miRNAs act as a host barrier during cross-species infection of influenza A virus.

2020年11月23日 · 在AIV感染过程中，在PAM细胞中筛选出40个表达失调的mirna。其中，ssc-miR-221-3p和ssc-miR-222两种猪源性mirna可直接靶向病毒基因组，通过抑制抗凋亡蛋白HMBOX1的表达诱导细胞凋亡，从而抑制PAM细胞中AIV的感染和复制。

2019年11月29日 · 在AIV感染过程中，在PAM细胞中筛选出40个表达失调的mirna。其中，ssc-miR-221-3p和ssc-miR-222两种猪源性mirna可直接靶向病毒基因组，通过抑制抗凋亡蛋白HMBOX1的表达诱导细胞凋亡，从而抑制PAM细胞中AIV的感染和复制。

2023年11月22日 · In the current study, we investigated the systemic biological function of the chicken miRNA gga-miR-148a-3p on immune responses in chicken lines resistant and susceptible to HPAIV-H5N1. We found that gga-miR-148a expression in the lung tissue of H5N1-resistant chickens was significantly downregulated during HPAIV-H5N1 infection.

2025年3月3日 · Experimental evidence demonstrated that miR-18a-5p overexpression effectively inhibits H5N1 virus propagation through multiple mechanisms: (1) in vitro studies using A549 cells transfected with miR-18a-5p mimics showed a substantial reduction in viral replication; (2) animal models (mice and chickens) with elevated miR-18a-5p expression ...

通过在鸡成纤维细胞中过表达miR-148a-3p，研究人员发现miR-148a-3p可以直接抑制IFN-γ、MAPK11和TGF-β2等免疫相关基因的翻译，并通过调节MAPK信号通路和干扰素刺激基因等途径，对抗禽流感病毒的感染。

2019年7月12日 · 在AIV感染过程中，在PAM细胞中筛选出40个表达失调的mirna。 其中，ssc-miR-221-3p和ssc-miR-222两种猪源性mirna可直接靶向病毒基因组，通过抑制抗凋亡蛋白HMBOX1的表达诱导细胞凋亡，从而抑制PAM细胞中AIV的感染和复制。