2024年12月24日 · AKR1B10 (Aldo-Keto Reductase Family 1 Member B10) is a Protein Coding gene. Diseases associated with AKR1B10 include Hepatocellular Carcinoma and Gastric Adenosquamous Carcinoma. Among its related pathways are Visual phototransduction and Cyclophosphamide Pathway, Pharmacodynamics.

2024年3月30日 · 一项发表在《Hepatology》的大规模多中心研究已经证实了AKR1B10可作为原发性肝细胞癌的血清标志物，且AKR1B10具有优于AFP的诊断价值。 蛋白质组学国家重点实验室的周钢桥教授团队基于蛋白质组学分析筛选出1983个HCC相关蛋白，经过分层筛选并通过血清验证再次证实了AKR1B10是HCC 的有效血清标志物，且术后AKR1B10血清水平显著下降，可作根治性手术疗效评估指标。 研究队列及方法: 发现队列：对10对HCC和邻近非肿瘤肝组织进行基于同位 …

Aldo-keto reductase family 1 member B10 is an enzyme that in humans is encoded by the AKR1B10 gene. [5] [6] [7] This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses.

no.3 血清akr1b10对afp阴性的肝癌具有良好的诊断效果. 图3. 如图3所示，在所有对照组中，血清akr1b10对afp阴性的肝细胞癌仍有较高的诊断价值。这进一步证实了血清akr1b10可作为afp诊断肝癌的有力补充。 no.4 肝细胞癌患者手术切除后血清akr1b10水平显著下降. 图4

2025年2月8日 · AKR1B10 was the most efficient catalyst of the stoichiometric two-electron reduction of BQ. AKR1B10 was up-regulated in association with serum alpha-fetoprotein, and was an independent risk factor for hepatocellular carcinoma in chronic hepatitis C patients.

AKR1B10 is a 36-kDa cytosolic reductase with a high amino acid sequence identity to AKR1B15 (92%) [3] and AKR1B1 (71%), referred to as aldose reductase (AR) [4]. AKR1B10 displays enzymatic activity for substrates such as retinaldehyde [5, 6], lipid peroxidation products [7 - 9], and xenobiotics [10, 11].

2021年5月21日 · AKR1B10 is a human nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reductase belonging to the aldo-keto reductase (AKR) 1B subfamily. It catalyzes the reduction of aldehydes, some ketones and quinones, and interacts with acetyl-CoA carboxylase and heat shock protein 90α.

1989年11月6日 · AKR1B10 is a human nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reductase belonging to the aldo-keto reductase (AKR) 1B subfamily. It catalyzes the reduction of aldehydes, some ketones and quinones, and interacts with acetyl-CoA carboxylase and heat shock protein 90?.

摘要: 目的探索肝细胞癌（HCC）中醛酮还原酶家族1成员B10（AKR1B10）的生物学功能和相关的病理机制。 方法通过CCLE数据库分析正常肝细胞与HCC细胞系中AKR1B10 mRNA的表达,UALCAN以及Oncomine数据库分析癌旁组织与HCC组织中AKR1B10 mRNA的表达,Western Blot法验证HCC患者癌组织与癌旁组织中AKR1B10蛋白表达差异。 使用慢病毒分别敲减HepG2及Huh7细胞中的AKR1B10,分为对照组和AKR1B10敲减组（shAKR1B10 1#、shAKR1B10 2#） …

2024年5月27日 · Hepatocellular carcinoma (HCC) represents a major global health threat with diverse and complex pathogenesis. Aldo-keto reductase family 1 member B10 (AKR1B10), a tumor-associated enzyme, exhibits abnormal expression in various cancers. However, a comprehensive understanding of AKR1B10's role in HCC …