The removal of ALDH1A1 in mice through genetic knockout results in viable animals that are fertile and healthy. The only validated phenotype of these mice is a resistance to high fat diet-induced obesity [14] while whole body ALDH1A1 removal does not affect fertility or neurological function. This biology closely replicates the clinical profile of Antabuse (disulfiram).

2024年12月24日 · ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) is a Protein Coding gene. Diseases associated with ALDH1A1 include Alcohol Dependence and Anaerobic Meningitis.Among its related pathways are Oxidation by cytochrome P450 and Fructose metabolism.Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and acyl-CoA dehydrogenase activity.

2021年12月26日 · 针对aldh1a1发挥促进乳腺癌的具体机制，他们设计了一种联合治疗策略以更高效的靶向治疗恶性乳腺癌。他们使用可以清除mdscs的化疗药物吉西他滨和 ...

2025年3月4日 · Title: The Molecular Context of Oxidant Stress Response in Cancer Establishes ALDH1A1 as a Critical Target: What This Means for Acute Myeloid Leukemia. The Prognostic Value of Cancer Stem Cell Markers (CSCs) Expression-ALDH1A1, CD133, CD44-For Survival and Long-Term Follow-Up of Ovarian Cancer Patients.

2024年10月1日 · 研究者通过RNA-seq等发现并验证：KRAS G12C抑制剂 （Sotorasib和Adagrasib） 处理后的细胞系中，ALDH1A1基因表达及酶活性显著上调。 基因敲除和过表达 （ALDH1A1野生型和酶活性缺失突变型） 、以及ALDH1A1特异性抑制剂CM10的实验结果表明：ALDH1A1的酶活性是其介导KRAS G12C抑制剂耐药性的关键因素。

Aldehyde Dehydrogenase-1A1 (ALDH1A1) and Chemoresistance. ALDH1A1 is also considered a highly conserved homo-tetramer (∼55 kDa monomer), with the retina being its preferred location. 67 The important role of ALDH1A1 involves the formation of transcriptional regulators essential for normal cell growth and differentiation. Additionally, ALDH1A1 is involved in the oxidation of retinaldehyde to ...

2021年1月1日 · ALDH1A1 is widely expressed in varieties of human organs and tissues, such as brain, liver, kidneys, adipose, eyelens, retina, and so forth. A key role that ALDH1A1 exhibits is the oxidation of retinaldehyde to retinoic acid (RA), forming transcriptional regulators critical for normal cell growth and differentiation [32].

醛脱氢酶 1 家族成员 A1： 该基因编码的蛋白质属于醛脱氢酶家族。醛脱氢酶是酒精代谢主要途径中继醇脱氢酶之后的下一个酶。肝脏中有两种主要的醛脱氢酶同工酶，胞质和线粒体，它们由不同的基因编码，可以通过它们的电泳迁移率、动力学特性和亚细胞定位来区分。该基因编码细胞溶质 …

2022年6月22日 · ALDH1A1 expression is regulated by several epigenetic processes. ALDH1A1 also acted as a tumor suppressor in certain cancers. The detoxification of ALDH1A1 often causes chemotherapy failure. Currently, ALDH1A1-targeted therapy is widely used in cancer treatment, but the mechanism by which ALDH1A1 regulates cancer development is not fully ...

2016年3月8日 · In cancer therapy, ALDH1A1 provides a useful therapeutic CSC target in tissue types that normally do not express high levels of ALDH1A1, including breast, lung, esophagus, colon and stomach. Here we review the functions and mechanisms of ALDH1A1, the key ALDH isozyme linked to SC populations and an important contributor to CSC function in ...