Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene. [5][6] Anaplastic lymphoma kinase (ALK) was originally discovered in 1994 [5][7] in …

2024年12月24日 · ALK (ALK Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ALK include Neuroblastoma 3 and Neuroblastoma. Among its related pathways are ASP-3026-resistant ALK mutants and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity.

The ALK gene provides instructions for making a protein called ALK receptor tyrosine kinase, which is part of a family of proteins called receptor tyrosine kinases (RTKs). Learn about this gene and related health conditions.

alk基因融合是指alk发生断裂并与其他基因融合，翻译后alk融合蛋白构象改变，影响自身磷酸化，而导致肿瘤的发生。 ALK融合后的致瘤活性是由其融合伴侣决定的，ALK融合伴侣介导的ALK融合可不依赖其配体形成二聚体并使蛋白激酶域活化。

2025年3月7日 · Genetic alterations of ALK in cancer include chromosomal rearrangements, activating point mutations or ALK protein overexpression that typically supports oncogenesis by inducing constitutive...

2025年1月4日 · This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain.

Anaplastic lymphoma kinase (ALK) is a tyrosine kinase associated with Anaplastic Large Cell lymphoma (ALCL) through oncogenic translocations mainly NPM-ALK. Chemotherapy is effective in ALK (+) ALCL patients and induces remission rates of approximately 80%.

2021年11月24日 · Our data reveal a mechanism of RTK activation that allows dimerization by either dimeric (ALKAL2) or monomeric (ALKAL1) ligands. This mechanism is underpinned by an unusual architecture of the...

2010年2月1日 · ALK is a membrane associated tyrosine kinase receptor of the insulin receptor superfamily. The function of the full-length ALK receptor is poorly understood. It has a probable role in the central and peripheral nervous system development and maintenance.

5 天之前 · FISH evaluation for ALK gene rearrangement was performed on the 5 µm lung cancer tissue sections using the ALK dual color, break-apart rearrangement probe (Anbiping, Guangzhou, China). The probe contains two differently labeled probes on opposite sides of the breakpoint of the ALK gene. A probe approximately 250 kb for the telomeric side of ...