Activin receptor type-1B is a protein that in humans is encoded by the ACVR1B gene. [5][6] ACVR1B or ALK-4 acts as a transducer of activin or activin-like ligands (e.g., inhibin) signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. These go on to recruit the R-SMADs SMAD2 or SMAD3. [7] .

alk4 是脊椎动物发育的重要调节因子，在中胚层诱导、原条形成、原肠胚形成、背前模式和左右轴确定中发挥作用。 来自不同物种的 alk4 (acvr1b) 蛋白的氨基酸序列非常稳定，由此得出结论，alk4 在进化过程中只发生了轻微的变化，在人和动物中，其功能相似.

使 Smad2 和 Smad3 磷酸化的主要是TGF-β亚家族（ALK4，ALK5和ALK7）的I型受体（PS：基于ALK5的抑制剂开发较多），而Smad3对诱导HSCs活化和促纤维化基因转录至关重要。另，Smad3缺乏会导致脂肪组织中的巨噬细胞表型改变，这对脂肪的形成也很重要。

2024年12月24日 · ACVR1B (Activin A Receptor Type 1B) is a Protein Coding gene. Diseases associated with ACVR1B include Pancreatic Cancer and Transposition Of The Great Arteries, Dextro-Looped. Among its related pathways are NF-kappaB Pathway and Human Embryonic Stem Cell Pluripotency.

2021年8月1日 · ALK4, ALK5, or ALK7 antagonism pivots around small-molecule inhibitors. The small-molecule inhibitors work by occupying the adenosine triphosphate binding site of the ALK kinase, thereby obstructing its phosphorylation of Smad2/3 [45].

2019年5月3日 · The present results show that neurons and microglia both use ALK4/5 (a type of TGF-β receptor) signaling in order to maintain mutual exchanges in an adult brain following an axonal injury....

Vactosertib 还以纳摩尔浓度抑制 ALK2 和 ALK4 (IC50 为 17.3 nM)，具有强大的抗转移活性和抗癌作用。 GW788388 有效的 ALK5 抑制剂，IC50 值 18 nM。

ALK（anaplastic lymphoma kinase，间变性淋巴瘤激酶）属于受体型PTKs家族，主要在神经系统表达，是目前研究相对较多的一种PTKs，它与多种肿瘤的发生有着密切的联系。 本文就ALK蛋白在肿瘤中的变异及靶向治疗手段进行总结和回顾。 1. ALK结构与下游信号通路. ALK是一种受体酪氨酸激酶，属于 胰岛素受体超家族。 人 ALK基因 位于2号染色体p23.2-p23.1，编码1620个氨基酸，经过翻译后修饰生成200～220kDa的成熟ALK蛋白。 ALK在神经系统的发育和功能中扮演重 …

2024年12月24日 · ALK (ALK Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ALK include Neuroblastoma 3 and Neuroblastoma. Among its related pathways are ASP-3026-resistant ALK mutants and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity.

Antisense oligonucleotides (AONs) were designed specifically to block the function of ALK4, a key receptor for the MSTN/activin pathway in skeletal muscle. AON-induced exon skipping resulted in specific Alk4 down-regulation, inhibition of MSTN activity, and increased myoblast differentiation in vitro Unexpectedly, a marked decrease in muscle ...