New function of the myostatin/activin type I receptor (ALK4) as a ...
Real-time qPCR was performed to measure full-length Alk4 transcript down-regulation and myogenic gene expression. The data are presented as the average of the results of 3 …
ALK4-SMAD2/3-SMAD4 signaling mediates the activin A
2019年8月1日 · The mRNA levels of PTX3, ALK4, and ALK5 were examined using RT-qPCR. The results are expressed as the mean ± SEM of 6 independent experiments, and values …
Activin a inhibits foam cell formation and up-regulates ABCA1 and …
2021年10月1日 · Alk4 is required for activin A-mediated anti-atherogenic effects. Activin A inhibits cholesterol uptake through a Smad2-dependent pathway. Smad2 and Smad3 form …
Competition between type I activin and BMP receptors for binding …
2022年2月18日 · Our results show that ACVR2A can form stable heteromeric complexes with ALK4 (an activin type I receptor), as well as with several BMP type I receptors (ALK2/3/6). Of …
ALK4-SMAD3/4 mediates the effects of activin A on the …
2020年4月5日 · The mRNA levels of ALK4 and ALK5 were examined using RT-qPCR. (B) SVOG cells (n = 4) were transfected with siCtrl, siALK4 or siALK5 for 48 h, and then treated with 30 …
Efficient Downregulation of Alk4 in Skeletal Muscle After Systemic ...
2023年2月1日 · Remaining Alk4 transcript was assessed by qPCR in the tibialis anterior (TA), gastrocnemius (Gas), diaphragm (Dia), heart (Ha), and liver (Li). (B) Remaining Alk4 transcript …
[Up-regulated expression of miR-576 inhibits ALK4 expression
The effects of miR-576 on the mRNA and protein expressions and phosphorylation levels of the ALK4 and JAK/STAT signaling pathway factors JAK2 and STAT3 were determined by qPCR …
Activin a inhibits foam cell formation and up-regulates ABCA1
The mRNA and protein levels of cholesterol receptors were analyzed by RT-qPCR and western blot analysis, respectively. To investigate whether activin receptor-like kinase 4 (Alk4) is …
Rapid detection and genotyping of ALK fusion variants by …
2019年10月22日 · We developed a high-resolution melting (HRM) assay to rapidly detect ALK fusions and automatically distinguish at least 20 fusion variants in one tube. Adapter multiplex …
Nodal/Activin Signaling Drives Self-Renewal and Tumorigenicity of ...
Knockdown or pharmacological inhibition of the Nodal/Activin receptor Alk4/7 in cancer stem cells virtually abrogated their self-renewal capacity and in vivo tumorigenicity, and reversed the …