2018年5月26日 · An ALP bone isoenzyme test can detect abnormal levels of bone growth that may be associated with bone disease or another serious condition. Learn more about the purpose of this test....

2020年9月5日 · Among various isoforms, the tissue-nonspecific isozyme of ALP (TNAP) is strongly expressed in bone, liver and kidney and plays a key function in the calcification of bones. TNAP hydrolyzes pyrophosphate and supplies inorganic phosphate to enhance mineralization.

Key Takeaways: High Alkaline Phosphatase High ALP Levels indicate various bone disorders requiring diagnosis. Paget’s Disease leads to abnormal bone formation and elevated ALP levels. Osteomalacia results from vitamin D deficiency, causing increased ALP production.

Bone alkaline phosphatase (BAP) is the bone-specific isoform of alkaline phosphatase. A glycoprotein that is found on the surface of osteoblasts, BAP reflects the biosynthetic activity of these bone-forming cells. BAP has been shown to be a …

2020年8月20日 · Alkaline phosphatases (ALPs) are a group of isoenzymes located on the outer layer of the cell membrane. They catalyze the hydrolysis of organic phosphate esters found in the extracellular space. Zinc and magnesium are essential cofactors of this enzyme.

2021年11月4日 · An alkaline phosphatase (ALP) test measures the amount of ALP in your blood. Although ALP exists throughout your body, the two main sources of ALP in your blood are your liver and bones. High levels of ALP may indicate liver disease or certain bone disorders, but an ALP test alone cannot diagnose a condition.

Bone alkaline phosphatase (bone ALP) is an ectoenzyme on the outer surface of the cell membrane of osteoblasts. It is partly released into the circulation. Bone ALP and liver ALP constitute about 95% of the total ALP activity in human serum.

2020年2月1日 · Bone alkaline phosphatase (BALP) is essential for biomineralization. Recent findings demonstrate a crucial role for BALP in the pathogenesis of vascular calcification and identified it as a promising predictor of mortality in CKD.

2024年9月21日 · Alkaline phosphatase (ALP) is a crucial enzyme found in various tissues throughout the body, including the liver, bone, kidney, and intestine. Its primary function is to catalyze the hydrolysis of phosphate esters, playing a vital role in mineralization and bone growth.

2024年12月4日 · Additionally, ALP isoenzymes can be used to monitor the effectiveness of treatment and predict disease outcomes. Diagnostic Applications. ALP isoenzymes have a range of diagnostic applications, including: Bone-related disorders: TNAP is a key marker for bone-related disorders, such as osteomalacia, rickets, and Paget's disease.