ALP inhibitors can reduce the growth and invasion of cancer cells. In all, ALP might be a potential tumor biomarker, and a potential therapeutic target. Red arrows indicate upregulated expression levels and green arrows indicate downregulated expression levels.

In this case, 3 different methods were used to determine the source of increased ALP in a patient with metastatic bone disease and no history of liver dysfunction. The correct interpretation of the initial bone ALP result by immunoassay was instrumental in the subsequent diagnosis and treatment of a previously undiagnosed liver condition.

2016年12月22日 · Recent evidence suggests that bone-related parameters are the main prognostic factors for overall survival in advanced prostate cancer (PCa), with elevated circulating levels of alkaline...

Serum alkaline phosphotase (ALP) levels are frequently elevated in patients with metastatic colorectal cancer (CRC). However, the significance of ALP in terms of detecting hepatic metastasis or prognosis is not well established.

2021年2月1日 · Patients with solid cancer and bone lesions have a higher mean level of ALP (187.1 U/L) compared with MM (123.8 U/L) while the lowest levels of ALP can be found in …

Applications and limitations of alkaline phosphatase as a tumor marker are discussed. This review focuses on three characteristic isoenzymes that have been found in the serum of cancer patients: (1) the Regan isoenzyme in bronchogenic carcinoma; (2) the Nagao isoenzyme in pleuritis carcinomatosa; an …

2025年1月3日 · Alkaline phosphatase (ALP), a tumor marker, indicates cancer presence and progression. High ALP levels accompany various cancers like bone, liver, intestinal, and breast cancers. ALP contributes to bone mineralization, tumor cell …

2019年1月17日 · The finding of an elevated serum alkaline phosphatase level in a patient with a heat-stable fraction strongly suggests that the placenta or a tumor (the Regan isoenzyme) is the source.

2025年1月10日 · In this article, we have underlined the recent advances (2019 onwards) of alkaline phosphatase in the arena of emerging cancer theranostics. Herein, we mainly focused on phosphate-locked molecular systems such as peptides, prodrugs, and aggregation-induced emission (AIE)-based molecules.

2020年10月27日 · Alanine aminotransferase (ALT) is an enzyme in the liver that rearranges the building blocks of proteins. It is released from damaged liver cells. Cancer patients may experience liver damage as a side effect of some cancer treatments or due to spread of cancer to their liver. ALT may also be referred to as SGPT (serum glutamic pyruvic transferase.)