2024年12月25日 · GFER (Growth Factor, Augmenter Of Liver Regeneration) is a Protein Coding gene. Diseases associated with GFER include Myopathy, Mitochondrial Progressive, With Congenital Cataract And Developmental Delay and Congenital Cataract-Progressive Muscular Hypotonia-Hearing Loss-Developmental Delay Syndrome.

2022年11月1日 · Augmenter of liver regeneration (ALR), a ubiquitous fundamental life protein, is expressed more abundantly in the liver than other organs. Expression of ALR is highest in hepatocytes, which also constitutively secrete it. ALR gene transcription is regulated by NRF2, FOXA2, SP1, HNF4α, EGR-1 and AP1/AP4. ALR’s FAD-linked sulfhydryl oxidase ...

肝再生增强因子 (augmenter of liver regeneration, ALR)是肝细胞的生存因子, 他存在于线粒体、胞浆、内质网以及胞核之中, 与酵母菌的存活能力必需基因1 (essential for respiratory and viability 1, EERV1)蛋白质具有高度同源性 [1 - 3]. 线粒体中ALR可能参与细胞氧化磷酸化过程, 具有巯基氧化酶和细胞色素C还原酶的作用, 并促进Fe/S蛋白的成熟. ALR由肝细胞分泌, 在枯否细胞中通过G-蛋白耦联的受体刺激肿瘤坏死因子-α (tumor necrosis factor alpha, TNF-α)、白介素 (interleukin, …

Augmenter of liver regeneration (ALR) gene transfection alleviates mitochondrial injury, through inhibiting fission and promoting fusion of the mitochondrial inner membrane, both of which contribute to reduction of HK-2 cell apoptosis.

2025年1月4日 · Augmenter of liver regeneration (ALR) gene transfection alleviates mitochondrial injury, through inhibiting fission and promoting fusion of the mitochondrial inner membrane, both of which contribute to reduction of HK-2 cell apoptosis.

1996年1月1日 · We report here the complete (i.e., genomic) nucleotide sequence of the mouse ALR gene, as well as its mRNA transcript. We also report on ALR mRNA expression and its product presence in mouse tissues. In addition, we report the sequence of human ALR, and its comparison with the rat and mouse sequences.

肝再生增强因子(alr)除了促进肝再生,保护肝损伤之外,可能在肝脏的器官形成和发育中也发挥着重要作用。介绍了alr在肝脏中的生物学功能和机制研究的最新进展,并归纳总结了alr在肝脏疾病的诊断和治疗中的应用。

2011年1月3日 · 肝再生增强因子（augmenterofliverregeneration，ALR）是由Hagiya于1994年从新生鼠肝脏中分离出的一种能促进肝脏再生的物质，克隆了它的cDNA（1）。 随后我们和国内其它单位相继克隆出人的同源性因子，并成功构建了它的真、原核重组表达载体和进行了高效表达（2，3，4）。 ALR与酵母菌的scERV1基因产物在氨基酸序列上有近50%相同，而scERV1基因对酵母菌线粒体的发生、酵母菌的生成和细胞周期的调节都是必不可少的（5）。 从生物近化的 …

The gene encodes a 125-amino acid polypeptide with a calculated molecular weight of 15,081 Da, consistent with its electrophoretically determined molecular weight under reducing conditions. The deduced primary sequence is 50% homologous to the polypeptide encoded by the scERV1 oxidative phosphorylation and vegetative growth gene in S. cerevisiae.

2012年4月5日 · The mammalian growth factor erv1-like (GFER) gene encodes a sulfhydryl oxidase enzyme, named Augmenter of Liver Regeneration (ALR). Recently it has been demonstrated that ALR supports cell ...