The ALS Therapy Development Institute (ALS TDI) is the Drug Discovery Engine for ALS – we work relentlessly to discover and invent ALS treatments in our labs and advance them into clinical trials. ALS TDI incorporates all aspects of drug discovery under one roof to find treatments as quickly as possible.

Explore the promising treatments developed at ALS TDI and learn about their current stage in the drug development process below. You can learn more about the phases of drug development here.

Take a look inside the ALS TDI labs to learn why ALS TDI is the Drug Discovery Engine for ALS and see how our science teams are working to invent and discover new ALS treatments.

ALS TDI was the first organization to run an open research program, posting in real time the results of its studies for patients, doctors, and the research community. It also pioneered a new model for engaging patients and families in fundraising and actively involving them in …

2025年1月6日 · ALS TDI is a global leader in this critical work. In 2024, we advanced two new mouse models, Profilin1 and TDP43, for use in testing potential therapies. By integrating them with our existing models, we evaluated dozens of therapeutic approaches tailored to …

2025年2月14日 · Now, thanks to a growing interest from first responders across the country in joining the fight against ALS, Arrest and Extinguish ALS is coming back in 2025 as a nationwide program at ALS TDI.

ARC is an evolution of ALS TDI's Precision Medicine Program (PMP) – the longest-running natural history study in ALS. The PMP was initially made possible through funds raised by the ALS Ice Bucket Challenge and ALS TDI will continue to collect data through the ARC study.

ALS is a complex disease that varies from person to person. Far more research is necessary to discover effective treatments for each person living with ALS. That's why researchers at the ALS Therapy Development Institute (ALS TDI) are working diligently to find treatments.

2024年10月4日 · Dr. Vieira dove into the key challenges ALS researchers face today and how ALS TDI is tackling them head-on, utilizing cutting-edge technologies and strategic partnerships to explore groundbreaking paths in ALS research. He discussed how ALS TDI is focused on developing a range of targeted therapies – including small molecules, protein ...

Through this collaborative study, ALS TDI partners with people living with ALS all over the world to gather data about the progression of ALS and advance our ALS drug discovery efforts. Participants share data on their movement, lifestyle, medical history, genetics, biomarkers, voice recordings and patient cell biology to inform ALS research.