Fusion gene map of acute leukemia revealed by transcriptome
2021年6月16日 · Here we report the FG map revealed by WTS in a consecutive cohort of 1000 acute leukemia cases in a single center, including 539 acute myeloid leukemia (AML), 437 …
More than a fusion gene: the RUNX1-RUNX1T1 AML | Blood
2019年3月7日 · The cytogenetics show a typical pattern of loss of the sex chromosome and del9q. These characteristics resulted in RUNX1 - RUNX1T1 –mutated AML being designated …
Fusion Gene Map of Acute Myeloid Leukemia Revealed By …
2020年11月5日 · We aimed to identify novel fusion transcripts with clinical relevance and delineate a comprehensive map of FGs in AML based on a large cohort using WTS. We …
Precision Medicine for High-Risk Gene Fusions in Paediatric AML: …
2025年1月16日 · Robust genetic characterization of paediatric AML has demonstrated that fusion oncogenes are highly prevalent drivers of AML leukemogenesis in young children.
Precision Medicine for High-Risk Gene Fusions in Paediatric AML: …
2025年1月14日 · Robust genetic characterization of paediatric AML has demonstrated that fusion oncogenes are highly prevalent drivers of AML leukemogenesis in young children. …
Acute myeloid leukemia fusion proteins deregulate genes …
Acute myelogenous leukemias (AMLs) are genetically heterogeneous and characterized by chromosomal rearrangements that produce fusion proteins with aberrant transcriptional …
Gene Fusion Detection By RNA-Seq in Acute Myeloid Leukemia (AML)
2019年11月13日 · Accurate and complete genetic classification of AML is crucial for the prediction of clinical outcome and treatment stratification.
Transcriptomic characterisation of acute myeloid leukemia cell …
3 天之前 · Transcriptomic characterisation of AML cell line models All AML cell lines used in this study belong to the same subtype (M5) classification of the FAB system [13]. THP-1, MOLM …
Precision Medicine for High-Risk Gene Fusions in Paediatric AML: …
Robust genetic characterization of paediatric AML has demonstrated that fusion oncogenes are highly prevalent drivers of AML leukemogenesis in young children. Identification of fusion …
Fusion Gene-Based Classification of Variant Cytogenetic ... - MDPI
2023年2月3日 · The classification of AML with recurrent chromosomal translocations, including those involving core binding factor subunits, plays a critical role in diagnosis, prognosis, …