2021年6月16日 · Core binding factor acute myelogenous leukemia (CBF-AML), characterized by the presence of either t (8;21) (q22;q22) or inv (16) (p13q22)/t...

2021年5月13日 · The fusion oncogene CBFβ-SMMHC expressed in AML with the chromosome inversion inv (16) (p13q22) acts as a driver oncogene in hematopoietic stem cells and induces AML.

2003年7月15日 · Acute myeloid leukemias (AMLs) carrying inv (16)/t (16;16) chromosomal abnormalities are associated with a good prognosis. However, studies of this AML subtype have been hampered by the few number of patients reported, frequently collectively considered with those with AML carrying the t (8;21) translocation.

2018年11月29日 · A subtype of patients with core binding factor acute myeloid leukemia (AML) is characterized by the presence of the presence of inv(16)(p13q22) and rarely by a translocation t(16;16)(p13;q22). The final genetic product is the fusion of the CBFβ gene at 16q22 to the smooth muscle myosin heavy chain (MYH11) at 16p13, which is termed as CBFβ ...

CBF-AML参与此染色体上的遗传物质倒置过程（在医学上被记作inv (16)），会使得16号染色体上两个基因，CBFB和MYH11发生融合。 相对较少的情况是，16号染色体参与的重组，在医学上被记为t (16;16)，导致同样以上两个基因出现融合。 以上基因重组作用下合成的蛋白被称为CBFβ-MYH11合成蛋白。 此融合蛋白能生成核心结合因子，但是医学界一般认为：此融合蛋白中的MYH11部分会使得此类核心结合因子无法再与DNA结合，从而影响此类因子控制基因活性的 …

2003年7月15日 · Acute myeloid leukemias (AMLs) carrying inv (16)/t (16;16) chromosomal abnormalities are associated with a good prognosis. However, studies of this AML subtype have been hampered by the few number of patients reported, frequently collectively considered with those with AML carrying the t (8;21) translocation.

Objectives: Acute myeloid leukemia (AML) with inv(16)/t(16;16) is among the most frequent AML subtypes. It is recognized by the detection of the CBFB-MYH11 fusion which confers a favorable prognosis, irrespective of the presence of secondary cytogenetic abnormalities.

2020年1月30日 · Abnormalities of chromosome 16 are found in about 5–8% of acute myeloid leukemia (AML). The AML with inv(16)(p13.1q22) or t (16;16)(p13.1;q22) is associated with a high rate of complete remission (CR) and favorable overall …

inv(16) ，是一种急性髓细胞白血病（AML）相关的染色体异常，预后良好。BCR-ABL和inv(16)的共同发生极为罕见。 2018年，美国的Ruiz S等人报道了一例罕见的t(9;22)和 inv(16)并存病例。 一、患者简介

2021年5月13日 · The fusion oncogene CBFβ-SMMHC expressed in AML with the chromosome inversion inv(16)(p13q22) acts as a driver oncogene in hematopoietic stem cells and induces AML. This review focuses on novel insights regarding the molecular mechanisms involved in CBFβ-SMMHC–driven leukemogenesis and recent advances in therapeutic approaches to target ...