Here we review the most important AML mouse models of each category, briefly describe their advantages and limitations and show how they have contributed to our understanding of the biology and to the development of novel therapies.

2015年3月20日 · Herein, we report experimental conditions (bone marrow preconditioning and injected cell number) for a faster and easier preclinical mouse model of AML based on the xenotransplantation of a...

Genetic alteration of human CD34+ hematopoietic cells and transplantation into immunodeficient mice provides a humanized mouse model to study the leukemic potential of mutations and chromosomal aberrations found in AML without the potential confounding effects of the co-occurring mutations inherent to human AML cell lines and primary patient ...

2014年9月2日 · Immunocompromised mice xenografted with NPM1 -mutated AML served as the first valuable tool for defining the biology of the disease in vivo. Subsequently, genetically engineered mouse models of...

Modeling of HSC-derived AML driven by a strong oncogene in mice has revealed a particularly invasive and drug-resistant phenotype associated with a genetic signature that also characterizes human AML with poor outcome.

2019年1月1日 · Dekkers and coresearchers developed X-ray and neutron exposed AML mice models which gave insights toward the genesis of AML in humans exposed to ionizing radiations and estimated dose dependent risks [38].

2022年9月16日 · Acute myeloid leukemia (AML) is one of the most common and fatal forms of hematopoietic malignancies. Here, we describe a mouse MLL-AF9 _AML model to investigate AML. We have optimized the protocols for retrovirus infection, bone marrow transplantation (BMT), and leukemia monitoring to create a stable mouse model.

Immunocompromised mice xenografted with NPM1-mutated AML served as the first valuable tool for defining the biology of the disease in vivo. Subsequently, genetically engineered mouse models of the NPM1 mutation, including transgenic and knock-in alleles, allowed the generation of mice with a constant genotype and a reproducible phenotype.

2015年3月20日 · The aim of the present work was to develop an improved preclinical mouse model of AML, broadening and increasing the use and quality of studies performed in the model, by: (i) performing serial retransplantation of primary AML cells to repetitively provide PDX cells for in vitro and in vivo studies; (ii) introducing genetic engineering of PDX ...

2019年1月21日 · Here we review the most important AML mouse models of each category, briefly describe their advantages and limitations and show how they have contributed to our understanding of the biology and to the development of novel therapies.