Human AP endonuclease (APE1), like most AP endonucleases, is of class II and requires an Mg 2+ in its active site in order to carry out its role in base excision repair. The yeast homolog of …

除 DNA 修复活性外，APE 1 还能通过氧化还原机制（Ref-1）在体外调控多种转录因子的 DNA 结合活性。APE 1 已被证实能刺激 Fos-Jun 异源二聚体、Jun-Jun 同源二聚体、Hela 细胞 AP-1 …

摘要：脱嘌呤/脱嘧啶核酸内切酶1 (Apurinic/apyrimidinic endonuclease 1，APE1)是一种广泛存在于生物体内、在碱基切除修复 (Base excision repair，BER)过程中能够在碱基缺失位点 (AP …

2022年9月14日 · Here, we determine how the base excision repair (BER) endonuclease AP-endonuclease 1 (APE1) recognizes and cleaves DNA damage in the nucleosome. Kinetic …

APE1 is an essential enzyme in the base excision repair pathway of DNA lesions caused by oxidation and alkylation. As importantly, APE1 also functions as a redox agent maintaining …

Human apurinic/apyrimidinic endonuclease 1 (APE1) is the primary cellular apurinic/apyrimidinic (AP) endonuclease, playing a pivotal role in not only the removal and repair of numerous DNA …

2015年10月12日 · DNA apurinic-apyrimidinic (AP) sites are prevalent noncoding threats to genomic stability and are processed by AP endonuclease 1 (APE1). APE1 incises the AP-site …

The mammalian AP-endonuclease (APE1/Ref-1) plays a central role in the repair of oxidized and alkylated bases in mammalian genomes via the base excision repair (BER) pathway. …

2025年1月14日 · The enzyme apurinic/apyrimidinic endonuclease 1 (APE1) initiates repair of AP-sites by cleaving the DNA backbone at the AP-site via its endonuclease activity. Here, we …

Human apurinic/apyrimidinic endonuclease 1(APE1) is an essential BER protein that is involved in the processing of potentially cytotoxic abasic sites that are obligatory intermediates in BER. …