APL-1, a Caenorhabditis elegans protein related to the human β ... - PNAS
2007年2月6日 · The nematode Caenorhabditis elegans has a single APP -related gene, apl-1, that is expressed in multiple tissues. Loss of apl-1 disrupts several developmental processes, …
APL-1, the Alzheimer’s Amyloid Precursor Protein in
2012年6月1日 · Caenorhabditis elegans encodes one APP-related protein, APL-1, which is essential for viability. Here, we show that APL-1 signaling is dependent on the activity of the …
APL-1, the Alzheimer’s Amyloid Precursor Protein in …
Caenorhabditis elegans encodes one APP-related protein, APL-1, which is essential for viability. Here, we show that APL-1 signaling is dependent on the activity of the FOXO transcription …
Amyloid Precursor Protein Trafficking, Processing, and Function
In Caenorhabditis elegans, deficiency in the ortholog APL-1 disrupts molting and morphogenesis and results in larval lethality. Interestingly, the APL-1 lethality can be rescued by neuronal …
APL-1, an altered peptide ligand derived from heat-shock
APL-1 is an altered peptide ligand derived from a novel CD4 + T cell epitope of human heat-shock protein of 60 kDa (HSP60), an autoantigen involved in the pathogenesis of rheumatoid arthritis …
Alzheimer-related protein APL-1 modulates lifespan through ...
We propose that reinforcing APL-1 expression in the hypodermis preserves the regulation of heterochronic lin-14 gene network to improve maintenance of somatic tissues via DAF …
apl-1 Amyloid-beta-like protein [ Caenorhabditis elegans ]
2024年12月27日 · Title: APL-1, the Alzheimer's Amyloid precursor protein in Caenorhabditis elegans, modulates multiple metabolic pathways throughout development.
APL-1, an altered peptide ligand derived from human heat-shock …
2013年12月1日 · This new peptide, called APL-1, behaves as an altered peptide ligand (APL) because, contrary to the wild type peptide (E18-3), it induced an increment of CD4 + CD25 …
APL-1, the Alzheimer's Amyloid precursor protein in …
Caenorhabditis elegans encodes one APP-related protein, APL-1, which is essential for viability. Here, we show that APL-1 signaling is dependent on the activity of the FOXO transcription …
Intracellular Trafficking and Synaptic Function of APL-1 in
2010年9月20日 · The aldicarb hypersensitivity can be rescued by full length APL-1 in a dose dependent fashion. At the cellular level, kinesins UNC-104/KIF-1A and UNC-116/kinesin-1 are …