ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membranes and transmembrane protein cargo.

2024年12月24日 · ARF6 (ADP Ribosylation Factor 6) is a Protein Coding gene. Diseases associated with ARF6 include Cholera and Fetal Akinesia Deformation Sequence 4. Among its related pathways are Vesicle-mediated transport and Rab regulation of trafficking.

ARF6（ADP-Ribosylation Factor 6）是小GTPase家族中的一员，主要参与调控细胞膜的重塑和囊泡运输。ARF6在 细胞内膜系统 的功能调节和细胞信号转导中扮演着重要角色。本文旨在探讨ARF6 重组蛋白 在细胞功能中的作用及其 信号通路 的潜在机制。 ARF6重组蛋白：目录 号 ...

2023年10月1日 · ADP-ribosylation factor 6 (Arf6), a small G-protein of the Ras superfamily, plays pivotal roles in multiple cellular events, including exocytosis, endocytosis, actin remodeling, plasma membrane reorganization and vesicular transport. Arf6 regulates the progression of cancer through the activation of cell motility and invasion.

2006年5月1日 · ARF6 localizes to the plasma membrane and endosomal compartments, in which it regulates clathrin-dependent endocytic membrane trafficking, as well as the trafficking and...

2023年10月18日 · Arf6被认为是癌症治疗的潜在靶点。Arf6的激活受多种GEF的调节，包括细胞粘附素、EFA6和BRAG家族。最初发现Arf6调节肿瘤细胞中的细胞运动和侵袭/转移 ...

Arf6 influences membrane trafficking and the actin cytoskeleton at the plasma membrane (PM). The goal of this review is to summarize these recent findings and provide a cellular context for understanding Arf6 function.

Arf6 regulates the progression of cancer through the activation of cell motility and invasion. Aberrant Arf6 activation is a potential therapeutic target. This review aims to understand the comprehensive function of Arf6 for future cancer therapy. The Arf6 GEFs, protein structure, and roles in cancer have been summarized.

2019年5月5日 · The small GTase Arf6 has several important functions in intracellular vesicular trafficking and regulates the recycling of different types of cargo internalized via clathrin-dependent or -independent endocytosis. It activates the lipid modifying enzymes PIP 5-kinase and phospholipase D, promotes act …

2023年2月22日 · ADP ribosylation factor 6 (Arf6) is a small GTPase that promotes the assembly of actin necessary for CME. In its absence, growth factor signaling is greatly diminished, which has been shown to ameliorate pathological signaling input in diseased vasculature.