Achaete-scute homolog 1 is a protein that in humans is encoded by the ASCL1 gene. [5] [6] Because it was discovered subsequent to studies on its homolog in Drosophila, the Achaete-scute complex, it was originally named MASH-1 for mammalian achaete scute homolog-1. [7]

2024年12月24日 · ASCL1 (Achaete-Scute Family BHLH Transcription Factor 1) is a Protein Coding gene. Diseases associated with ASCL1 include Haddad Syndrome and Congenital Central Hypoventilation Syndrome. Among its related pathways are Signaling by NTRKs and Nuclear Events (kinase and transcription factor activation).

2022年4月27日 · We identified enhancer regions bound by ASCL1 that lost their corresponding gene expression following ASCL1 knockdown, subsequent pathway analysis revealed loss of stem and neuronal programming...

Ascl1单一因子诱发的星形胶质细胞的转分化可在幼年脑（出生后两周）和成年脑中实现。 这一项研究成果建立了一种在体转分化高效获得功能性神经元的新方法，为实现疾病脑或创伤脑中在位完成神经修复提供了一条潜在的重要途径。

achaete-scute 家族 bHLH 转录因子 1： 该基因编码基本螺旋-环-螺旋 (BHLH) 转录因子家族的成员。该蛋白通过结合 E 盒 (5'-CANNTG-3') 激活转录。有效的 DNA 结合需要与其他 BHLH 蛋白二聚化。这种蛋白质在神经元的定型和分化以及嗅觉和自主神经元的产生中发挥作用。在极少数情况下，该基因的突变可能导致 ...

2015年3月10日 · The proneural transcription factor Ascl1 sequentially activates target genes in proliferating and differentiating progenitors during neurogenesis. Here Raposo et al. show that Ascl1 binds closed and open chromatin in proliferating cells. Binding to closed chromatin promotes accessibility and activation of differentiation specific genes.

2023年12月26日 · ASCL1 represses the MES gene signature, but activates the ADRN gene signature via regulation of various signaling pathways and cooperation with other ADRN CRC members. ASCL1 is essential for the maintenance of ADRN state of neuroblastoma cells.

2019年5月13日 · The divergent Ascl1 and Neurog2 binding patterns result in distinct chromatin accessibility and enhancer activity profiles that differentially shape the binding of downstream transcription...

Among Ascl1's direct targets, Klf10 regulates the neuritogenesis of iN cells at the early stage, Myt1 and Myt1l are critical for the electrophysiological maturation of iN cells, and Neurod4 and Chd7 are required for the efficient conversion of astrocytes into neurons.

2025年2月8日 · Ascl1 modulates multiple steps of oligodendrocyte precursor cell development in the postnatal brain and in response to demyelinating insults. Ascl1 directly regulates expression of matrix metalloproteinase-7 and O(6)-methylguanine-DNA methyltransferase.