The AST/ALT ratio or De Ritis ratio is the ratio between the concentrations of two enzymes, aspartate transaminase (AST) and alanine transaminase, aka alanine aminotransferase (ALT), in the blood of a human or animal.

2024年12月22日 · The result obtained via the AST ALT ratio calculator may provide you with a confirmation that your liver insufficiency was caused by alcohol. A high ratio and elevated levels of AST and ALT help the clinicians to make the correct diagnosis, discover the cause, and implement proper treatment.

The plasma levels of enzymes expressed in the liver—such as gamma-glutamyl transpeptidase (GGT), the aspartate aminotransferase (AST):alanine aminotransferase (ALT) ratio, and the mean corpuscular volume (MCV) of erythrocytes—are among the commonly used markers to identify chronic alcohol use (Hannuksela et al., 2007).

Most patients with high alcohol consumption but without severe liver disease do not have an AST/ALT ratio above 1. High AST/ALT ratio suggests advanced alcoholic liver disease.

2004年7月1日 · Results: There was a significant rise in the AST/ALT ratio from the W to the S patients, and from the S to the C patients. In the W group, the ratio was ≤1.0 in 64% of the patients, and only exceptionally ≥2. In the C group, 69% had a ratio ≥2, and 8% a ratio ≤1.0. The mean ratio was midway in the S group.

All patients with elevated transaminases should be counseled about moderation or cessation of alcohol use, weight loss, and avoidance of hepatotoxic drugs. Liver chemistry tests assess liver...

Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are liver-derived enzymes involved in amino acid metabolism and are commonly used as blood biomarkers of heavy alcohol drinking. ALT and AST levels in the blood may be elevated after heavy consumption of alcohol and remain elevated after alcohol use for as long as 2–3 weeks ...

2024年9月12日 · An AST/ALT ratio equal to 1 (where the ALT is equal to the AST) may indicate acute viral hepatitis or hepatotoxicity. An AST/ALT ratio higher than 1 (where the AST is higher than ALT) indicates cirrhosis. An AST/ALT ratio higher than 2:1 (where the AST is more than twice as high as the ALT) is a common sign of alcoholic liver disease.

2025年2月19日 · Elevated AST levels, similar to ALT, can signify liver damage. Levels above 40 U/L may be a cause for concern, and higher levels indicate more severe damage. GGT is also found in several tissues, including the liver. Similar to aspartate transaminases, elevated GGT levels are associated with alcohol-related liver disease.

In the cohort of 78 patients with alcoholic cirrhosis (age 55, 26–75; 58% male) 70 had a normal ALT and 12 had a normal AST. The average AST for all patients was 59U/L ± 34U/L (ULN=35U/L), and the average ALT was 27U/L ± 13U/L (ULN=45U/L).