ASXL1 Gene - GeneCards | ASXL1 Protein | ASXL1 Antibody
2024年12月24日 · ASXL1 (ASXL Transcriptional Regulator 1) is a Protein Coding gene. Diseases associated with ASXL1 include Bohring-Opitz Syndrome and Myelodysplastic Syndrome. …
分子细胞生物学团队揭示ASXL1突变促进白血病发生发展的新机制
2020年7月30日 · ASXL1（Additional sex combs-like）与BAP1（BRCA1-associated protein 1）组成的PR-DUB蛋白复合物是一类重要的表观遗传调控因子，它通过催化组蛋白H2AK119ub的 …
ASXL1 - Wikipedia
In Drosophila, the Additional sex combs (Asx) gene encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a …
血液肿瘤相关基因介绍 - 知乎 - 知乎专栏
ASXL1是慢性粒单核细胞白血病（CMML）CMML中最常见的基因突变，有ASXL1突变的CMML患者易进展为AML，是预后差的因素。 在约15%的CML急变期患者中会出现ASXL1突变。 突变 …
Mutations in ASXL1 are associated with poor prognosis across the ...
2012年3月21日 · The ASXL1 gene can be translocated and fused to the PAX5 gene in acute lymphoblastoid leukemia and altered by germ-line mutations in the Bohring-Opitz syndrome; …
Role of ASXL1 in Hematopoiesis and Myeloid Diseases - PMC
Mutations in Additional sex combs-like 1 (ASXL1), a chromatin regulator, are identified in clonal hematopoiesis of indeterminate potential (CHIP), indicating ASXL1 mutations as early events …
ASXL1 ASXL transcriptional regulator 1 [ (human)] - National …
2025年2月8日 · ASXL1 encodes a polycomb repressive complex protein implicated in chromatin regulation and de novo mutations are a known cause of Bohring-Opitz syndrome. Data …
ASXL1 gene - MedlinePlus
More than 20 mutations in the ASXL1 gene have been found to cause Bohring-Opitz syndrome, a condition that causes abnormal head size and shape, distinctive facial features, joint …
ASXL1 interacts with the cohesin complex to maintain chromatid ...
We report that ASXL1 interacts with the cohesin complex, which has been shown to guide sister chromatid segregation and regulate gene expression. Loss of Asxl1 impairs the cohesin …
The role of ASXL1 in hematopoiesis and myeloid malignancies
An epigenetic regulator, Additional sex combs-like 1 (ASXL1), is one of the most frequently mutated genes in all subtypes of myeloid malignancies. ASXL1 mutations are also frequently …