ATF6 - Wikipedia
Activating transcription factor 6, also known as ATF6, is a protein that, in humans, is encoded by the ATF6 gene [5][6][7] and is involved in the unfolded protein response. ATF6 is an …
ATF6 Gene - GeneCards | ATF6A Protein | ATF6A Antibody
2024年12月24日 · ATF6 (Activating Transcription Factor 6) is a Protein Coding gene. Diseases associated with ATF6 include Achromatopsia 7 and Achromatopsia. Among its related …
细胞凋亡全集之内质网主导的细胞凋亡 - 知乎 - 知乎专栏
atf6是内质网膜上的ii型跨膜蛋白。 ATF6的N端胞内区域包含了b-ZIP的DNA转录激活域和核定位信号。 在非应激状态下，以酶原的形式分布于内质网膜上。
Molecular mechanism of ATF6 in unfolded protein response and …
2024年3月15日 · Activating transcription factor 6 (ATF6), an important signaling molecule in unfolded protein response (UPR), plays a role in the pathogenesis of several diseases, …
A lifetime of stress: ATF6 in development and homeostasis
2018年5月25日 · Best known for its role in transducing signals linked to stress to the endoplasmic reticulum, the 50 kDa activated form of ATF6 is now emerging as a major regulator of …
中科院和北京大学合作揭示内质网应激蛋白ATF6调节人干细胞衰老 …
2018年1月11日 · ATF6作为内质网UPR中关键的应激蛋白，当受到压力时被切割为具有转录因子活性的蛋白，并从高尔基体膜转位至细胞核中，激活靶基因的表达；从而参与调控内质网应激反 …
ATF6 在未折叠蛋白反应中的分子机制及其在疾病中的作用,Heliyon …
2024年2月10日 · 激活转录因子 6 （ATF6） 是未折叠蛋白反应 （UPR） 中的重要信号分子，在多种疾病的发病机制中发挥作用，包括先天性视网膜疾病、肝纤维化和强直性脊柱炎等疾病。 …
The unfolded protein response regulator ATF6 promotes ... - Science
ATF6(N) is a basic leucine zipper (bZIP)–class transcriptional activator that, once untethered from the membrane, migrates to the nucleus to up-regulate ER protein–folding chaperones and …
Endoplasmic reticulum stress: molecular mechanism and …
2023年9月15日 · Facing ER stress, ATF6 is transported to the Golgi apparatus and cleaved by Site-1 (S1P) and Site-2 (S2P) proteases. After the cleavage, ATF6 releases a cytosolic …
ATF6 - an overview | ScienceDirect Topics
ATF6 is an ER type-II transmembrane protein with a N-terminal cytoplasmic region containing a bZIP and DNA transcription activation domain and a C-terminal lumenal region that senses ER …