Endoplasmic reticulum stress: molecular mechanism and
2023年9月15日 · Accumulation of misfolded and unfolded protein in endoplasmic reticulum (ER) will replace the BiP binding on PERK, ATF6 and IRE1, and activate them. PERK causes the …
Molecular mechanism of ATF6 in unfolded protein response and …
2024年3月15日 · After endoplasmic reticulum stress (ERS), ATF6 is activated after separation from binding immunoglobulin protein (GRP78/BiP) in the endoplasmic reticulum (ER) and …
ER Stress Induces Cleavage of Membrane-Bound ATF6 by the …
ATF6 is a membrane-bound transcription factor that activates genes in the endoplasmic reticulum (ER) stress response. When unfolded proteins accumulate in the ER, ATF6 is cleaved to …
ER Stress Regulation of ATF6 Localization by ... - ScienceDirect
2002年7月1日 · ATF6 is an endoplasmic reticulum (ER) stress-regulated transmembrane transcription factor that activates the transcription of ER molecular chaperones. Upon ER …
A lifetime of stress: ATF6 in development and homeostasis
2018年5月25日 · Activating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known …
ER stress signaling has an activating transcription factor 6α (ATF6 ...
2018年11月23日 · In response to an accumulation of unfolded proteins in the endoplasmic reticulum (ER) lumen, three ER transmembrane signaling proteins, inositol-requiring enzyme 1 …
The unfolded protein response regulator ATF6 promotes ... - Science
ATF6 encodes a transcription factor that is anchored in the endoplasmic reticulum (ER) and activated during the unfolded protein response (UPR) to protect cells from ER stress. Deletion …
ER stress induces cleavage of membrane-bound ATF6 by the same ... - PubMed
ATF6 is a membrane-bound transcription factor that activates genes in the endoplasmic reticulum (ER) stress response. When unfolded proteins accumulate in the ER, ATF6 is cleaved to …
ER stress signaling by regulated proteolysis of ATF6
2005年4月1日 · ATF6 is an endoplasmic reticulum (ER) membrane-anchored transcription factor activated by intramembrane proteolysis in the ER stress response. Upon ER stress, ATF6 is …
ER Stress Activates the TOR Pathway through Atf6 - PMC
2018年4月23日 · Activating transcription factor 6 (Atf6), a major stress-responsive ER transmembrane protein, is responsible for ER stress-induced TOR activation. Supporting the …