2023年9月15日 · Facing ER stress, ATF6 is transported to the Golgi apparatus and cleaved by Site-1 (S1P) and Site-2 (S2P) proteases. After the cleavage, ATF6 releases a cytosolic …

分析后生动物 ATF6 在拟南芥中的同源基因，发现拟南芥 bZIP 家族的转录因子中，有 75 个成员具有类似于 ATF6 的特征，预测为二类跨膜蛋白。 其中 bZIP17/28/49 三个成员与之十分相似， …

于是作者通过测量 Xbp1s （由IRE1介导的剪接Xbp1转录本）和Hspa5（ATF6目标基因）的总体种群水平表达来监测IRE1和ATF6的活性。研究人员验证了Xbp1s和Hspa5在Tm处理开始后的12 …

2018年8月7日 · Treatment with 147 alters the migration of FT ATF6 in non-reducing gels (upward gel shift), consistent with a net reduction of the disulfides in ATF6. Similar results were …

2017年10月13日 · We recently isolated ATF6 as a candidate for mammalian UPR-specific transcription factor. We report here that ATF6 constitutively expressed as a 90-kDa protein …

2007年9月4日 · ATF6α is neither essential for basal expression of ER protein chaperones nor for embryonic or postnatal development. However, ATF6α is required in both cells and tissues to …

2018年1月5日 · Our study unravels the first ATF6-regulated gene expression network related to homeostatic regulation of membrane organelles, and provides novel mechanistic insights into …

2020年10月1日 · Ileal IECs from patients with CD have higher levels of activated ATF6, which is regulated by CSNK2B and HSPA5. ATF6 increases expression of TNF and other inflammatory …

We recently isolated ATF6 as a candidate for mammalian UPR-specific transcription factor. We report here that ATF6 constitutively expressed as a 90-kDa protein (p90ATF6) is directly …

AAVR knockdown enhances ATF6 signaling in the UPR induced by TM. ER stress is induced by various assaults and elicits complex downstream signaling. The UPR is a common cause of …