2017年9月13日 · As the Atg4 activity is essential and highly specific to autophagy, Atg4 is a prospective target for developing autophagy-specific inhibitors. In this review article, we …

自噬由数十种自噬相关 (Atg) 蛋白介导，其中 Atg4 是唯一通过 Atg8 的加工和解偶联来调节自噬的蛋白酶。 由于 Atg4 活性对于自噬至关重要且具有高度特异性，因此 Atg4 是开发自噬特异性 …

As the Atg4 activity is essential and highly specific to autophagy, Atg4 is a prospective target for developing autophagy-speci c inhibitors. In this review article, we summarize our current...

2017年8月18日 · In this study, we describe a novel regulatory mechanism, in which the Atg1 kinase specifically inhibits the deconjugating activity of Atg4 at the PAS, possibly contributing …

ATG-4 main deployments - squadron overview and aircraft in use March 1956 - September 1956 (Pacific Ocean) aboard USS Yorktown (CVA 10) Fighter Squadron 94 (VF-94) '?'

2012年7月16日 · In vitro enzymatic analysis revealed that ATG-4.1 processes LGG-1 precursors about 100 fold more efficiently than ATG-4.2. Expression of a mutant form LGG-1, which …

2017年9月1日 · Autophagy is mediated by dozens of autophagy-related (Atg) proteins, among which Atg4 is the sole protease that regulates autophagy through the processing and …

Atg4 is the sole cysteine protease among dozens of Atg proteins and functions as an essential factor in the Atg8 conjugation system. While only one Atg4 is present in yeast, there are four …

This study demonstrates that ATG-4 isoforms can be specialized to perform distinct functions, from autophagosome biogenesis (through ATG-4.1, and also ATG-4.2) to autophagic vacuole …

2021年2月15日 · ATG4 is a key Cys-protease with a dual function in both ATG8 lipidation and free ATG8 recycling whose balance is crucial for proper biogenesis of the autophagosome.