Boosting ATM activity alleviates aging and extends lifespan in a …
2018年5月2日 · Molecularly, ATM phosphorylates SIRT6 deacetylase and thus prevents MDM2-mediated ubiquitination and proteasomal degradation. Extra copies of Sirt6 extend lifespan in …
Boosting ATM activity alleviates aging and extends lifespan in a …
2018年5月2日 · Molecularly, ATM phosphorylates SIRT6 deacetylase and thus prevents MDM2-mediated ubiquitination and proteasomal degradation. Extra copies of Sirt6 extend lifespan in …
ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization …
2015年12月29日 · H2AX stabilization is mediated by the ATM kinase, sirtuin protein SIRT6, and ISWI family chromatin remodeler SNF2H. This enables efficient γH2AX foci formation and …
Adipose sirtuin 6 drives macrophage polarization toward M2
2019年5月21日 · Sirt6 transgenic mice show reduced fat mass, lower LDL cholesterol and triglyceride levels, and improved glucose tolerance, and these effects are mediated by …
ATM and SIRT6/SNF2H Mediate Transient H2AX ... - ScienceDirect
2015年12月29日 · Our results reveal a pathway controlled by ATM, SIRT6, and SNF2H to block HUWE1, which stabilizes H2AX and induces its incorporation into chromatin only when cells …
SIRT6, a Mammalian Deacylase with Multitasking Abilities
2019年10月30日 · Another study in C. elegans deficient for the DNA repair factor Atm, which display reduced lifespan, increased copies of Sirt6 restore lifespan and metabolic homeostasis …
SIRT6调控血管钙化的作用及其机制研究-学位-万方数据知识服务 …
Sirtuin6(SIRT6)是一种组蛋白去乙酰化酶，可参与调控DNA损伤修复。 已有研究报道，SIRT6可以通过减轻血管平滑肌细胞的DNA损伤缓解小鼠动脉粥样硬化。 然而，目前关于SIRT6是否通 …
Restoration of energy homeostasis by SIRT6 extends healthy …
2021年5月28日 · Here, we show that SIRT6 overexpression leads to a reduction in frailty and lifespan extension in both male and female B6 mice. A combination of physiological assays, in …
ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When ... - PubMed
2015年12月29日 · H2AX Ser139, the ATM phosphorylation site, was essential for H2AX stabilization upon DSB formation. Our results reveal a pathway controlled by ATM, SIRT6, and …
Our results reveal a pathway controlled by ATM, SIRT6, and SNF2H to block HUWE1, which stabilizes H2AX and induces its incorporation into chromatin only when cells are damaged.