The mission of the AAVR is to promote veterinary radiology education and responsible practices in diagnostic imaging for general practice veterinarians and veterinary technicians through certification programs, educational courses, and practice guidelines.

Among other factors consistent with the known pathways of entry and infection, the authors identified a new cellular factor that is required for infection of multiple AAV serotypes, which they term AAV receptor (AAVR).

2023年3月20日 · 腺相关病毒 (Adeno-associated virus, AAV) 是一类无被膜、具有二十面体结构、直径20~26nm之间、含有4.70kb线性单链DNA基因组的细小病毒 [1]。AAV载体具有体内表达时间长、宿主范围广、免疫原性低、安全性高等优点, 是基因治疗研究中名副其实的“明星分子”。早在2012年, 第一个以AAV为基因载体的基因治疗药物Glybera在欧盟获批上市, 用于治疗脂蛋白脂肪酶缺乏症 (Lipoprotein lipase deficiency, LPLD) 。 随着AAV基础研究和临床试验的日益增多, 有 …

2016年1月27日 · We characterize AAVR as a protein capable of rapid endocytosis from the plasma membrane and trafficking to the trans -Golgi network. We show that AAVR directly binds to AAV2 particles, and that...

2024年10月20日 · 高分辨率冷冻电子显微镜（cryo-EM）结构详细说明了腺相关病毒（AAV）受体蛋白的结合相互作用。 AAV的糖基“主要受体”被重新定义为“附着因子”。 AAV5类病毒与受体的不同结构域相互作用，其结合位点与其他AAV不同。 许多AAV中和抗体的表位与衣壳上的受体结合位点重叠。 未来的结构研究重点将放在AAV受体非依赖途径以及进入和运输的其他步骤上。 1.病毒-宿主相互作用：改进基因治疗载体的基础. AAV（见术语表）是一种小的单链DNA病毒，属于细 …

aavr蛋白被证实是aav受体的一种，aavr是kiaao319l基因编码的一种免疫球蛋白样结构的跨膜蛋白，由一个信号引导域、一个n端跨膜域及胞内域、5个免疫球蛋白样胞外结构域（pkd1,pkd2,pkd3,pkd4,pkd5）和一个c端跨膜区及胞内域构成。

AAVRKO cells were still poorly infected by AAV2 at 100,000 viral genomes per cell. The importance of AAVR in AAV infection was validated by demonstrating that expression of recombinant AAVR in the AAVRKO cells rescued infection. Intriguingly, infection by distinct serotypes, including AAV1, AAV2, AAV3b, AAV5, AAV6, AAV8, and AAV9,

2016年4月1日 · A powerful genome-wide haploid genetic screen is employed to gain a better understanding of the AAV infectious entry pathway and identifies a new cellular factor required for infection of multiple AAV serotypes, which the authors term AAV receptor (AAVR).

AAVR examinations and their content are the property of AAVR. AAVR examinations are available only to those persons who desire in good faith to become certified by meeting AAVR requirements and successfully completing AAVR examinations.

2019年2月11日 · Adeno-associated virus (AAV) is a leading vector for virus-based gene therapy. The receptor for AAV (AAVR; also named KIAA0319L) was recently identified, and the precise...