Cryo-EM structure and polymorphism of Aβ amyloid fibrils …
2019年10月29日 · Transmission electron microscopy (TEM) analysis of negatively stained specimens reveals the elongated morphology of the fibrils in our samples (Supplementary Fig. …
Cryo-EM structures of amyloid-β 42 filaments from human brains
2022年1月13日 · Alzheimer’s disease is characterized by a loss of memory and other cognitive functions and the filamentous assembly of Aβ and tau in the brain. The assembly of Aβ …
Molecular Structure of β-Amyloid Fibrils in Alzheimer’s ... - Cell Press
Here, we investigate structures of human brain-derived Aβ fibrils, using seeded fibril growth from brain extract and data from solid-state nuclear magnetic resonance and electron microscopy.
Fibril structure of amyloid-β(1–42) by cryo–electron microscopy
2017年9月7日 · We present the structure of an Aβ (1–42) fibril composed of two intertwined protofilaments determined by cryo–electron microscopy (cryo-EM) to 4.0-angstrom resolution, …
Cryo-EM structures of amyloid-β 42 filaments from human brains
2022年1月14日 · Filament assembly of amyloid-β peptides ending at residue 42 (Aβ42) is a central event in Alzheimer’s disease. Here, we report the cryo–electron microscopy (cryo-EM) …
Cryo-EM structures of lipidic fibrils of amyloid-β (1-40)
2024年2月13日 · Here we present the cryo-electron microscopy (cryo-EM) structures of six lipidic Aβ40 fibrils that assemble from three filament folds, providing structural insights into fibril–lipid …
Cryo-EM of Aβ fibrils from mouse models find tg-APP - Nature
2023年11月16日 · We found novel Aβ fibril structures in the APP/PS1, ARTE10 and tg-SwDI models, whereas the human type II filament fold was found in the ARTE10, tg-APP Swe and …
Science | 阿尔兹海默病相关蛋白Aβ42纤维结构被揭示 - 知乎
这篇Science研究解析了Aβ42细丝结构特征，将为神经退行性疾病的个体诊断、治疗和新型Aβ抗体治疗提供关键信息和证据。 为此， Science 刊发了 Michael Willem 和 Marcus Fändrich 教授 …
(PDF) Imaging Abeta aggregation by liquid-phase ... - ResearchGate
2024年1月31日 · To achieve this goal, we apply liquid-phase transmission electron microscopy (LTEM) in combination with all-atom molecular dynamics simulations. Our results offer an initial...
2BEG: 3D Structure of Alzheimer's Abeta(1-42) fibrils - RCSB PDB
2005年10月24日 · Here, we present the 3D structure of the fibrils comprising Abeta (1-42), which was obtained by using hydrogen-bonding constraints from quenched hydrogen/deuterium …