ABO incompatibility exists when the mother has blood type “O,” and her baby has blood type “A,” “B,” or “AB.” For ABO incompatibility to be clinically relevant, it has to lead to hemolysis. Hemolysis is defined as the destruction of red blood cells.

In ABO hemolytic disease of the newborn (also known as ABO HDN) maternal IgG antibodies with specificity for the ABO blood group system pass through the placenta to the fetal circulation where they can cause hemolysis of fetal red blood cells which can lead to fetal anemia and HDN.

Risk factors for ABO incompatibility are present in 12–15% of pregnancies, but evidence of fetal sensitization (positive direct Coombs test) occurs in only 3–4%. Symptomatic ABO hemolytic disease occurs in <1% of all newborn infants but accounts for approximately two-thirds of observed cases of hemolytic disease in the newborn.

ABO incompatibility is the most common cause of hemolytic disease of the newborn (HDN) which occurs in 15 to 25% of pregnancies 1. ABO incompatibility happens when a mother’s blood type is type-O becomes pregnant with a fetus with a different blood type (type A, B, or AB) 2.

2024年6月17日 · When people who have one blood type receive blood from someone with a different blood type, it may cause their immune system to react. This is called ABO incompatibility. Due to modern testing techniques, this problem is very rare.

Major ABO incompatibility (e.g., Group O recipient receiving Group A HPC graft) is associated with immediate destruction of donor RBCs. However, the extent of clinical hemolysis depends on a combination of factors, including recipient’s isohemagglutinin titer …

2012年11月16日 · Although ABO incompatibility is common, its related hemolytic disease has been reported to be low. In this study, we aimed to investigate the rate of direct anti-globulin test (DAT) positivity and clinical events, such as hyperbilirubinemia or anemia in …

ABO incompatibility is a common and generally mild type of haemolytic disease in babies. The term haemolytic disease means that red blood cells are broken down more quickly than usual. Due to the increased breakdown of red blood cells, jaundice, anaemia, and in very severe cases can cause death, can result.

Isoimmune hemolytic anemia may result when ABO incompatibility occurs between the mother and the newborn infant. This disorder is most common with blood type A or B infants born to type O mothers. The hemolytic process begins in utero and is the result of active placental transport of maternal isoantibody.

In addition to transfusion, ABO incompatibility can cause hemolysis in hematopoietic and solid organ transplantation, hemolytic disease of the newborn, and intravenous immunoglobulin infusion. It is important to prevent ABO incompatibility when possible and to anticipate complications when ABO incompatibility is unavoidable.